Bassotti Gabrio, Villanacci Vincenzo, Corsetti Maura
Gastroenterology, Hepatology & Digestive Endoscopy Section, Department of Medicine and Surgery, University of Perugia, 06123 Perugia, Italy.
Pathology Institute, ASST-Spedali Civili, 25123 Brescia, Italy.
J Clin Med. 2023 Feb 20;12(4):1702. doi: 10.3390/jcm12041702.
Despite great progress in pharmaceutical research, the medical treatment of chronic idiopathic constipation is far from ideal. The aim of the present article was to review literature data, focusing on poorly studied or commercially unavailable/unapproved drugs potentially useful for the treatment of chronic idiopathic constipation in adults. An extensive online literature search was conducted using the keywords "chronic constipation", "colon", "constipation", "drugs", "laxatives", and "treatment", in various combinations between January 1960 and December 2022. The literature search showed the presence of some drugs whose efficacy has only recently been demonstrated by modern investigations, and which are likely to be incorporated into future guidelines, of others that are proven effective and potentially effective on constipated patients but limited by small or relatively old studies, or by side effects which could be used in experienced hands, and of others that might be useful but lack a solid scientific background. Looking into the future for patients with chronic constipation might add some more tools to the therapeutic portfolio, especially for certain subgroups of these patients.
尽管药物研究取得了巨大进展，但慢性特发性便秘的医学治疗仍远非理想。本文的目的是回顾文献数据，重点关注对成人慢性特发性便秘治疗可能有用但研究较少或商业上不可用/未获批准的药物。在1960年1月至2022年12月期间，使用关键词“慢性便秘”“结肠”“便秘”“药物”“泻药”和“治疗”的各种组合进行了广泛的在线文献检索。文献检索表明，存在一些药物，其疗效直到最近才通过现代研究得到证实，并且可能会被纳入未来的指南；还有一些药物已被证明对便秘患者有效且可能有效，但受到小型或相对陈旧研究的限制，或者受到副作用的限制，这些药物可由经验丰富的医生使用；另外还有一些药物可能有用，但缺乏坚实的科学背景。展望未来，对于慢性便秘患者可能会在治疗组合中增加更多工具，特别是对于这些患者的某些亚组。
