导致儿童易患真菌病的先天性免疫缺陷
Inborn Errors of Immunity Causing Pediatric Susceptibility to Fungal Diseases.
作者信息
Olbrich Peter, Vinh Donald C
机构信息
Pediatric Infectious Diseases, Rheumatology and Immunology Unit, Hospital Universitario, Virgen del Rocío, 41013 Sevilla, Spain.
Instituto de Biomedicina de Sevilla, IBiS/Universidad de Sevilla/CSIC, Red de Investigación Traslacional en Infectología Pediátrica RITIP, 41013 Sevilla, Spain.
出版信息
J Fungi (Basel). 2023 Jan 22;9(2):149. doi: 10.3390/jof9020149.
Inborn errors of immunity are a heterogeneous group of genetically determined disorders that compromise the immune system, predisposing patients to infections, autoinflammatory/autoimmunity syndromes, atopy/allergies, lymphoproliferative disorders, and/or malignancies. An emerging manifestation is susceptibility to fungal disease, caused by yeasts or moulds, in a superficial or invasive fashion. In this review, we describe recent advances in the field of inborn errors of immunity associated with increased susceptibility to fungal disease.
遗传性免疫缺陷是一组由基因决定的异质性疾病，会损害免疫系统，使患者易患感染、自身炎症/自身免疫综合征、特应性/过敏、淋巴增殖性疾病和/或恶性肿瘤。一种新出现的表现是易患由酵母或霉菌引起的浅表或侵袭性真菌病。在本综述中，我们描述了与真菌病易感性增加相关的遗传性免疫缺陷领域的最新进展。
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