Wysocki Matthew A, Doyle Scott T
Department of Pathology and Anatomical Sciences, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14260, USA.
J Pers Med. 2023 Feb 13;13(2):321. doi: 10.3390/jpm13020321.
Osteoporotic fractures of the femur are associated with poor healing, disability, reduced quality of life, and high mortality rates within 1 year. Moreover, osteoporotic fractures of the femur are still considered to be an unsolved problem in orthopedic surgery. In order to more effectively identify osteoporosis-related fracture risk and develop advanced treatment approaches for femur fractures, it is necessary to acquire a greater understanding of how osteoporosis alters the diaphyseal structure and biomechanical characteristics. The current investigation uses computational analyses to comprehensively examine how femur structure and its associated properties differ between healthy and osteoporotic bones. The results indicate statistically significant differences in multiple geometric properties between healthy femurs and osteoporotic femurs. Additionally, localized disparities in the geometric properties are evident. Overall, this approach will be beneficial in the development of new diagnostic procedures for highly detailed patient-specific detection of fracture risk, for establishing novel injury prevention treatments, and for informing advanced surgical solutions.
股骨骨质疏松性骨折愈合不良、导致残疾、生活质量下降，且1年内死亡率高。此外，股骨骨质疏松性骨折仍是骨科手术中一个尚未解决的问题。为了更有效地识别与骨质疏松相关的骨折风险并开发股骨骨折的先进治疗方法，有必要更深入地了解骨质疏松如何改变骨干结构和生物力学特性。当前的研究使用计算分析来全面研究健康骨骼和骨质疏松骨骼之间股骨结构及其相关特性的差异。结果表明，健康股骨和骨质疏松股骨在多个几何特性上存在统计学上的显著差异。此外，几何特性的局部差异也很明显。总体而言，这种方法将有助于开发新的诊断程序，用于高度详细的患者特异性骨折风险检测，用于建立新的损伤预防治疗方法，并为先进的手术解决方案提供依据。
