Jia Zhuangzhuang, Wang Shuai, Yan Haifeng, Cao Yawen, Zhang Xuan, Wang Lin, Zhang Zeyu, Lin Shanshan, Wang Xianliang, Mao Jingyuan
Department of Cardiovascular Diseases, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China.
Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
J Pers Med. 2023 Feb 19;13(2):366. doi: 10.3390/jpm13020366.
Pulmonary vascular remodeling is the critical structural alteration and pathological feature in pulmonary hypertension (PH) and involves changes in the intima, media and adventitia. Pulmonary vascular remodeling consists of the proliferation and phenotypic transformation of pulmonary artery endothelial cells (PAECs) and pulmonary artery smooth muscle cells (PASMCs) of the middle membranous pulmonary artery, as well as complex interactions involving external layer pulmonary artery fibroblasts (PAFs) and extracellular matrix (ECM). Inflammatory mechanisms, apoptosis and other factors in the vascular wall are influenced by different mechanisms that likely act in concert to drive disease progression. This article reviews these pathological changes and highlights some pathogenetic mechanisms involved in the remodeling process.
肺血管重塑是肺动脉高压（PH）的关键结构改变和病理特征，涉及内膜、中膜和外膜的变化。肺血管重塑包括肺中间膜肺动脉的内皮细胞（PAECs）和肺动脉平滑肌细胞（PASMCs）的增殖和表型转化，以及外层肺动脉成纤维细胞（PAFs）和细胞外基质（ECM）的复杂相互作用。血管壁中的炎症机制、细胞凋亡和其他因素受不同机制影响，这些机制可能协同作用推动疾病进展。本文综述了这些病理变化，并重点介绍了重塑过程中涉及的一些发病机制。
