Yu Suah, Ahn So Hyun, Choi Sang Hyoun, Ahn Woo Sang, Jung In-Hye
Department of Radiological Science, Kangwon National University, Samcheok 25949, Republic of Korea.
Korea Institute of Radiological & Medical Sciences, Seoul 01812, Republic of Korea.
Life (Basel). 2023 Jan 28;13(2):362. doi: 10.3390/life13020362.
In radiation therapy (RT) for skin cancer, tissue-equivalent substances called boluses are widely used to ensure the delivery of an adequate dose to the skin surface and to provide a radioprotective effect for normal tissue. The aim of this study was to develop a new type of three-dimensional (3D) bolus for RT involving body parts with irregular geometries and to evaluate its clinical feasibility. Two 3D-printed boluses were designed for two patients with squamous cell carcinoma (SCC) of their distal extremities based on computed tomography (CT) images and printed with polylactic acid (PLA). The clinical feasibility of the boluses was evaluated by measuring the in vivo skin dose at the tumor site with optically stimulated luminescence detectors (OSLDs) and comparing the results with the prescribed and calculated doses from the Eclipse treatment planning system (TPS). The average measured dose distribution for the two patients was 94.75% of the prescribed dose and 98.8% of the calculated dose. In addition, the average measured dose during repeated treatments was 189.5 ± 3.7 cGy, thus demonstrating the excellent reproducibility of the proposed approach. Overall, the customized 3D-printed boluses for the RT of distal extremities accurately delivered doses to skin tumors with improved reproducibility.
在皮肤癌的放射治疗（RT）中，一种被称为填充剂的组织等效物质被广泛用于确保向皮肤表面输送足够剂量的辐射，并为正常组织提供辐射防护作用。本研究的目的是开发一种新型的三维（3D）填充剂，用于涉及不规则几何形状身体部位的放射治疗，并评估其临床可行性。基于计算机断层扫描（CT）图像，为两名远端肢体鳞状细胞癌（SCC）患者设计了两种3D打印填充剂，并用聚乳酸（PLA）进行打印。通过使用光激发发光探测器（OSLDs）测量肿瘤部位的体内皮肤剂量，并将结果与Eclipse治疗计划系统（TPS）规定的剂量和计算剂量进行比较，来评估填充剂的临床可行性。两名患者的平均测量剂量分布为规定剂量的94.75%和计算剂量的98.8%。此外，重复治疗期间的平均测量剂量为189.5±3.7 cGy，从而证明了所提出方法具有出色的可重复性。总体而言，为远端肢体放射治疗定制的3D打印填充剂能够准确地向皮肤肿瘤输送剂量，且可重复性有所提高。
