Ricotti Rosalinda, Ciardo Delia, Pansini Floriana, Bazani Alessia, Comi Stefania, Spoto Ruggero, Noris Samuele, Cattani Federica, Baroni Guido, Orecchia Roberto, Vavassori Andrea, Jereczek-Fossa Barbara Alicja
Department of Radiation Oncology, European Institute of Oncology, Milan, Italy.
Department of Radiation Oncology, European Institute of Oncology, Milan, Italy.
Phys Med. 2017 Jul;39:25-32. doi: 10.1016/j.ejmp.2017.06.004. Epub 2017 Jun 21.
3D printing is rapidly evolving and further assessment of materials and technique is required for clinical applications. We evaluated 3D printed boluses with acrylonitrile butadiene styrene (ABS) and polylactide (PLA) at different infill percentage.
A low-cost 3D printer was used. The influence of the air inclusion within the 3D printed boluses was assessed thoroughly both with treatment planning system (TPS) and with physical measurements. For each bolus, two treatment plans were calculated with Monte Carlo algorithm, considering the computed tomography (CT) scan of the 3D printed bolus or modelling the 3D printed bolus as a virtual bolus structure with a homogeneous density. Depth dose measurements were performed with Gafchromic films.
High infill percentage corresponds to high density and high homogeneity within bolus material. The approximation of the bolus in the TPS as a homogeneous material is satisfying for infill percentages greater than 20%. Measurements performed with PLA boluses are more comparable to the TPS calculated profiles. For boluses printed at 40% and 60% infill, the discrepancies between calculated and measured dose distribution are within 5%.
3D printing technology allows modulating the shift of the build-up region by tuning the infill percentage of the 3D printed bolus in order to improve superficial target coverage.
3D打印技术正在迅速发展,临床应用需要对材料和技术进行进一步评估。我们评估了不同填充率下由丙烯腈丁二烯苯乙烯(ABS)和聚乳酸(PLA)3D打印而成的 bolus。
使用一台低成本3D打印机。通过治疗计划系统(TPS)和物理测量全面评估3D打印bolus中空气夹杂的影响。对于每个bolus,使用蒙特卡罗算法计算两个治疗计划,一种是考虑3D打印bolus的计算机断层扫描(CT),另一种是将3D打印bolus建模为具有均匀密度的虚拟bolus结构。使用Gafchromic薄膜进行深度剂量测量。
高填充率对应bolus材料内的高密度和高均匀性。当填充率大于20%时,在TPS中将bolus近似为均匀材料的效果令人满意。使用PLA bolus进行的测量与TPS计算的轮廓更具可比性。对于填充率为40%和60%打印的bolus,计算和测量的剂量分布之间的差异在5%以内。
3D打印技术允许通过调整3D打印bolus的填充率来调节剂量建成区的位移,以改善浅表靶区的覆盖。