Andreu-Noguera Julia, López-Botella Andrea, Sáez-Espinosa Paula, Gómez-Torres María José
Biotechnology Department, Science Faculty, University of Alicante, 03690 Alicante, Spain.
Life (Basel). 2023 Jan 29;13(2):364. doi: 10.3390/life13020364.
The unique properties of spermatozoa are established through the spermatogenesis and maturation processes concurrently with its epigenome. It is known that damage to epigenetic mechanisms can lead to reproductive problems. However, scientific reviews addressing the role of the spermatozoa epigenome during the reproductive process are scarce. Therefore, the aim of this review was to offer a detailed overview of current knowledge in the field of spermatozoa epigenetics and its consequent implications. A full search was performed through three databases by combining five keywords. Inclusion criteria were implemented to grant accessibility, relevance, and concretion. Besides, some articles were manually removed or added to obtain an adequate and complete collection of 485 scientific publications. This compilation was used to conduct the bibliometric analysis and the data review separately. Bibliometric results displayed that spermatozoa epigenetics is an active and growing research area. The bibliographic overview showed that sperm epigenome correlates with the development of its function, explaining the environmental influence on reproductive pathologies or abnormal inheritance. The main conclusions were that the normal performance of sperm is heavily reliant on its epigenetics and that this study area is burgeoning, with the potential ability to provide society with clinical innovations in a short-term period.
精子的独特特性是在精子发生和成熟过程中与其表观基因组同时建立的。众所周知，表观遗传机制的损伤会导致生殖问题。然而，针对精子表观基因组在生殖过程中作用的科学综述却很少。因此，本综述的目的是详细概述精子表观遗传学领域的现有知识及其相关影响。通过组合五个关键词在三个数据库中进行了全面搜索。实施了纳入标准以确保可及性、相关性和具体性。此外，手动删除或添加了一些文章，以获得485篇科学出版物的充分且完整的集合。该汇编分别用于进行文献计量分析和数据审查。文献计量结果显示，精子表观遗传学是一个活跃且不断发展的研究领域。文献综述表明，精子表观基因组与其功能的发育相关，解释了环境对生殖病理学或异常遗传的影响。主要结论是，精子的正常功能在很大程度上依赖于其表观遗传学，并且这个研究领域正在蓬勃发展，有潜力在短期内为社会提供临床创新。
