Zhang Min, Hu Shunze, Sun Xuying
Department of Orthopedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Department of Nursing, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Life (Basel). 2023 Jan 29;13(2):373. doi: 10.3390/life13020373.
Alzheimer's Disease (AD) and osteoporosis are both age-related degenerative diseases. Many studies indicate that these two diseases share common pathogenesis mechanisms. In this review, the osteoporotic phenotype of AD mouse models was discussed, and shared mechanisms such as hormonal imbalance, genetic factors, similar signaling pathways and impaired neurotransmitters were identified. Moreover, the review provides recent data associated with these two diseases. Furthermore, potential therapeutic approaches targeting both diseases were discussed. Thus, we proposed that preventing bone loss should be one of the most important treatment goals in patients with AD; treatment targeting brain disorders is also beneficial for osteoporosis.
阿尔茨海默病（AD）和骨质疏松症都是与年龄相关的退行性疾病。许多研究表明，这两种疾病具有共同的发病机制。在本综述中，讨论了AD小鼠模型的骨质疏松表型，并确定了诸如激素失衡、遗传因素、相似的信号通路和神经递质受损等共同机制。此外，该综述提供了与这两种疾病相关的最新数据。此外，还讨论了针对这两种疾病的潜在治疗方法。因此，我们提出预防骨质流失应是AD患者最重要的治疗目标之一；针对脑部疾病的治疗对骨质疏松症也有益。
