Murzilli Stefania, Mirone Vincenzo, Micheletto Marta, Tedesco Erik, Maira Giovanni Di, Benetti Federico, Vanelli Arianna
Nutrilinea srl, I-21013 Gallarate, Italy.
Department of Neurosciences, Sciences of Reproduction and Odontostomatology, University of Naples Federico II, I-80131 Naples, Italy.
Life (Basel). 2023 Jan 31;13(2):389. doi: 10.3390/life13020389.
Among the many factors inducing prostate inflammation, bacterial contribution is potentially underrated according to the scientific community. Bacterial prostatitis is characterized by modifications of the prostatic microenvironment, mainly driven by the immune system. Macrophages play a major role in bacterial prostatitis, secreting a plethora of proinflammatory and chemoattractive cytokines and proteolytic enzymes able to degrade the ECM, so facilitating the invasion of other immune cells. Consequently, macrophages represent a link between bacterial infection and prostate inflammation, as well as being the main target of prostate anti-inflammatory drugs and dietary supplements. This study aims to investigate the effect of a formulation composed of active principles and a probiotic strain with a particular focus on the anti-inflammatory effect in an in vitro bacterial prostatitis model. The results obtained showed that the formulation reduces the inflammatory response of prostatic epithelium induced by bacterial infection. This effect is mediated by the modulation of activated macrophages. Analysis of the cytokines released highlights that the tested formulation is able to reduce the expression of key proinflammatory cytokines involved in the pathogenesis of prostate diseases, in particular prostate cancer, and represents a valuable tool to prevent bacterial prostatitis and ensure favorable prostate health.
在引发前列腺炎症的众多因素中，科学界认为细菌的作用可能被低估了。细菌性前列腺炎的特征是前列腺微环境的改变，主要由免疫系统驱动。巨噬细胞在细菌性前列腺炎中起主要作用，分泌大量促炎和趋化性细胞因子以及能够降解细胞外基质的蛋白水解酶，从而促进其他免疫细胞的侵入。因此，巨噬细胞是细菌感染与前列腺炎症之间的联系，也是前列腺抗炎药物和膳食补充剂的主要靶点。本研究旨在研究一种由活性成分和益生菌菌株组成的制剂的效果，特别关注其在体外细菌性前列腺炎模型中的抗炎作用。所得结果表明，该制剂可降低细菌感染诱导的前列腺上皮细胞的炎症反应。这种作用是通过对活化巨噬细胞的调节介导的。对释放的细胞因子的分析表明，所测试的制剂能够降低参与前列腺疾病，特别是前列腺癌发病机制的关键促炎细胞因子的表达，是预防细菌性前列腺炎和确保前列腺健康的有价值工具。
