Alsubaie Faris Saad, Khataee Hamid, Neufeld Zoltan
School of Mathematics and Physics, The University of Queensland, Brisbane, QLD 4072, Australia.
Australian Bureau of Statistics, Brisbane, QLD 4000, Australia.
Life (Basel). 2023 Feb 2;13(2):427. doi: 10.3390/life13020427.
Mathematical and computational models are used to describe biomechanical processes in multicellular systems. Here, we develop a model to analyse how two types of epithelial cell layers interact during tissue invasion depending on their cellular properties, i.e., simulating cancer cells expanding into a region of normal cells. We model the tissue invasion process using the cellular Potts model and implement our two-dimensional computational simulations in the software package CompuCell3D. The model predicts that differences in mechanical properties of cells can lead to tissue invasion, even if the division rates and death rates of the two cell types are the same. We also show how the invasion speed varies depending on the cell division and death rates and the mechanical properties of the cells.
数学和计算模型用于描述多细胞系统中的生物力学过程。在此，我们开发了一个模型，以分析两种上皮细胞层在组织侵袭过程中如何根据其细胞特性相互作用，即模拟癌细胞向正常细胞区域扩展。我们使用细胞Potts模型对组织侵袭过程进行建模，并在软件包CompuCell3D中进行二维计算模拟。该模型预测，即使两种细胞类型的分裂率和死亡率相同，细胞力学性质的差异也会导致组织侵袭。我们还展示了侵袭速度如何根据细胞分裂率、死亡率以及细胞的力学性质而变化。
