Oguma Hidetoshi, Matsuda Yasuhiro, Yoshihara Kumiko, Okuyama Katsushi, Sakurai Masahiko, Saito Takashi, Inoue Satoshi, Yoshida Yasuhiro
Division of General Dentistry, Hokkaido University Hospital, Sapporo 060-8586, Japan.
Division of Clinical Cariology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Tobetsu 061-0293, Japan.
Materials (Basel). 2023 Feb 9;16(4):1454. doi: 10.3390/ma16041454.
Certain dentin hypersensitivity treatment materials include oxalic acid to coat dentin surfaces with minerals, while certain organic acids possess a remineralization effect. Herein, an organic acid that inhibits the demineralization and coating of root surfaces was evaluated. Specimens were produced using five non-carious extracted bovines. Four different acids were used: oxalic acid (OA), malonic acid (MA), polyacrylic acid (PA), and succinic acid (SA). Each acid was applied to the root surface and washed using distilled water or a remineralization solution, and the surface was observed using scanning electron microscopy (SEM). All the surfaces of each specimen, barring the polished surface, were covered with wax and immersed in an automatic pH cycling system for two weeks. Dentin demineralization was analyzed using transverse microradiography (TMR) before and after pH cycling. SEM analysis demonstrated that the three acid groups demineralized the dentin surface, whereas the OA group generated crystals covering the dentin surface, even in a distilled water environment. TMR analysis revealed that the OA groups showed significantly lower integrated mineral loss compared with the other groups, even in the distilled water environment. The results suggest that OA generates insoluble calcium oxalate crystals on the dentin and suppresses demineralization even under low saliva conditions.
某些牙本质过敏治疗材料含有草酸，可在牙本质表面形成矿物质涂层，而某些有机酸具有再矿化作用。在此，对一种抑制牙根表面脱矿和涂层形成的有机酸进行了评估。使用五颗非龋坏的拔除牛牙制作标本。使用了四种不同的酸：草酸（OA）、丙二酸（MA）、聚丙烯酸（PA）和琥珀酸（SA）。将每种酸应用于牙根表面，并用蒸馏水或再矿化溶液冲洗，然后使用扫描电子显微镜（SEM）观察表面情况。每个标本除抛光面外的所有表面均用蜡覆盖，并浸入自动pH循环系统中两周。在pH循环前后，使用横向微放射照相术（TMR）分析牙本质脱矿情况。SEM分析表明，三个酸组使牙本质表面脱矿，而OA组即使在蒸馏水环境中也能在牙本质表面生成晶体。TMR分析显示，即使在蒸馏水环境中，OA组的综合矿物质损失也显著低于其他组。结果表明，OA可在牙本质上生成不溶性草酸钙晶体，即使在低唾液条件下也能抑制脱矿。
