Kunkel R S
Department of Internal Medicine, Cleveland Clinic Foundation, Ohio.
Neuroepidemiology. 1987;6(4):209-13. doi: 10.1159/000110121.
Most prophylactic drug studies for migraine utilize parallel or crossover formats. Both study designs have disadvantages and advantages. The pros and contras of each study are discussed. The majority of headache investigators seem to favor the parallel study and reasons for this preference are discussed.
