Second Medical Clinic, School of Medicine, Ippokration Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece.
Midwifery Department, School of Healthcare Sciences, University of West Macedonia, Koila, 50100 Kozani, Greece.
Medicina (Kaunas). 2023 Jan 19;59(2):202. doi: 10.3390/medicina59020202.
The frail, elderly population is often characterized by poor immunogenicity post COVID-19 mRNA vaccination. "Inflame-ageing" and "immune-senescence" are pathogenetic mechanisms that might explain this phenomenon. Complex interplay with cytokines and microbiota is also implicated in this inflammatory cascade. The abovementioned population, although very important from immunologic perspective, has barely been included in the mRNA vaccination clinical trials.
脆弱的老年人群在感染 COVID-19 信使核糖核酸（mRNA）疫苗后往往表现出较差的免疫原性。“炎症衰老”和“免疫衰老”是可能解释这一现象的发病机制。细胞因子和微生物群之间的复杂相互作用也与这一炎症级联反应有关。上述人群虽然从免疫学角度来看非常重要，但几乎没有被纳入 mRNA 疫苗临床试验。
