Castillo-Mariqueo Lidia, Lagos Alejandro Aedo, Giménez-Llort Lydia, Oyarzo Neftalí Guzmán
Carrera de Kinesiología, Departamento de Procesos Terapéuticos, Facultad de Ciencias de la Salud, Universidad Católica de Temuco, Temuco 4780000, Chile.
Establecimiento de Larga Estadía para el Adulto Mayor (ELEAM) Santa Isabel de Traiguén, Traiguén 4730000, Chile.
Geriatrics (Basel). 2024 Dec 25;10(1):1. doi: 10.3390/geriatrics10010001.
Frailty is a common condition among older individuals and is associated with increased vulnerability to adverse health outcomes. The COVID-19 pandemic further highlighted the impact of viral infections on frail populations. The present work aimed to determine frailty, functional and cognitive status, and clinical analysis of older persons in a long-term care facility in Chile, before and following the outbreak of COVID-19. A single-center, pre-post, and Pearson's correlational study was conducted in a cohort of 20 persons positive for COVID-19 from a total of 45 residents. Data on demographic, clinical, functional (Barthel Index (BI) and Katz) and cognitive (Mini mental Examination) status, and physiological function (hematology, lipidic and biochemical profiles) were collected. The mean age was 84 ± 2.4 years, and 80% were females. The most common comorbidities were Arterial Hypertension, Diabetes Mellitus type II, and Alzheimer's disease. Physical frailty was confirmed by body weight, body mass index, and calf circumference. Pre-infection, BI was negatively correlated with lipidic profile and erythrocyte sedimentation rate (ESR), and positively with frailty (calf circumference). Pre-post analysis showed that frailty and most analytical results were not modified. However, functional dependence on daily live activities significantly increased as measured by BI, with worse grooming and bowel and bladder controls. Post-infection, correlations were lost except between BI and ESR, and decreased albumin levels were found. The worsening of specific functional limitations emphasizes the need for targeted interventions that can be correlated with ESR. Albumin appears as a potential biomarker for physiological dysfunction associated with their infectious/inflammatory processes.
衰弱是老年人中的常见状况，与不良健康结局的易感性增加相关。2019冠状病毒病（COVID-19）大流行进一步凸显了病毒感染对衰弱人群的影响。本研究旨在确定智利一家长期护理机构中老年人在COVID-19疫情爆发之前和之后的衰弱状况、功能和认知状态以及临床分析。对45名居民中20名COVID-19检测呈阳性的队列进行了一项单中心、前后对照和Pearson相关性研究。收集了人口统计学、临床、功能（Barthel指数（BI）和Katz指数）、认知（简易精神状态检查）状态以及生理功能（血液学、脂质和生化指标）的数据。平均年龄为84±2.4岁，80%为女性。最常见的合并症是动脉高血压、II型糖尿病和阿尔茨海默病。通过体重、体重指数和小腿围度确认身体衰弱。感染前，BI与脂质指标和红细胞沉降率（ESR）呈负相关，与衰弱（小腿围度）呈正相关。前后分析表明，衰弱和大多数分析结果没有改变。然而，根据BI测量，日常生活活动的功能依赖性显著增加，在修饰以及肠道和膀胱控制方面更差。感染后除了BI和ESR之间的相关性外，其他相关性均消失，且白蛋白水平降低。特定功能限制的恶化强调了需要进行与ESR相关的针对性干预。白蛋白似乎是与其感染/炎症过程相关的生理功能障碍的潜在生物标志物。
