Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.
School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.
Medicina (Kaunas). 2023 Feb 9;59(2):322. doi: 10.3390/medicina59020322.
: The prognoses of lung cancer deteriorate dramatically as the cancer progresses through its stages. Therefore, early screening using techniques such as low-dose computed tomography (LDCT) is critical. However, the epidemiology of the association between the popularization of CT and the prognosis for lung cancer is not known. : Data were obtained from GLOBOCAN and the health data and statistics of the World Health Organization. Mortality-to-incidence ratios (MIRs) and the changes in MIR over time (δMIR; calculated as the difference between MIRs in 2018 and 2012) were used to evaluate the correlation with CT density disparities via Spearman's rank correlation coefficient. : Countries with zero CT density presented a relatively low incidence crude rate and a relatively high MIR in 2018 and a negative δMIR. Conversely, countries with a CT density over 30 had a positive δMIR. The CT density was significantly associated with the HDI score and MIR in 2018, whereas it demonstrated no association with MIR in 2012. The CT density and δMIR also showed a significant linear correlation. : CT density was significantly associated with lung cancer MIR in 2018 and with δMIR, indicating favorable clinical outcomes in countries in which CT has become popularized.
肺癌的预后随着癌症分期的进展而急剧恶化。因此，早期使用低剂量计算机断层扫描（LDCT）等技术进行筛查至关重要。然而，CT 普及与肺癌预后之间的关联的流行病学尚不清楚。
数据来自 GLOBOCAN 和世界卫生组织的健康数据和统计。死亡率与发病率比（MIR）和随时间变化的 MIR 变化（δMIR；计算为 2018 年和 2012 年 MIR 之间的差异）用于通过 Spearman 秩相关系数评估与 CT 密度差异的相关性。
在 2018 年，CT 密度为零的国家的粗发病率相对较低，MIR 相对较高，且 δMIR 为负。相反，CT 密度超过 30 的国家具有正 δMIR。2018 年 CT 密度与 HDI 评分和 MIR 显著相关，而与 2012 年 MIR 无关。CT 密度和 δMIR 也显示出显著的线性相关性。
CT 密度与 2018 年的肺癌 MIR 显著相关，与 δMIR 也显著相关，表明 CT 普及的国家临床结果良好。
