Cadet J L, Rothman R B
Department of Neurology, Columbia University, College of Physicians and Surgeons, New York, NY 10032.
Neuropeptides. 1987 Aug-Sep;10(2):175-80. doi: 10.1016/0143-4179(87)90019-9.
Chronic treatment with IDPN causes a persistent behavioral syndrome which is reminiscent of the head shakes, backward locomotion, and hyperactivity observed after acute injection of 5-HT agonists in rodents. Evaluation of the characteristics of 5-HT receptors, using mianserin to label 5-HT-2 receptors, revealed a significant increase in the number of binding sites in the cortices of rats which demonstrated the IDPN-induced syndrome. There was an associated decrease in the affinity of the receptors. These results add more evidence to support the idea that the serotonergic system may play a significant role in the manifestation of the persistent abnormalities induced by IDPN.
用IDPN进行慢性治疗会导致一种持续的行为综合征，这让人联想到在啮齿动物中急性注射5-羟色胺（5-HT）激动剂后观察到的头部震颤、向后移动和多动。使用米安色林标记5-HT-2受体来评估5-HT受体的特性，结果显示，出现IDPN诱导综合征的大鼠皮质中结合位点的数量显著增加。同时，受体的亲和力下降。这些结果进一步证明，血清素能系统可能在IDPN诱导的持续性异常表现中发挥重要作用。
