Cadet J L, Rothman R B
Neurosci Lett. 1986 Dec 3;72(1):84-6. doi: 10.1016/0304-3940(86)90623-3.
Chronic administration of iminodipropionitrile (IDPN) causes a persistent behavioral syndrome which consists of hyperactivity, vertical neck dyskinesias and lateral head twitches. D-Ala-D-Leu-enkephalin binding revealed a 26% decrease in the number but no change in the affinity of delta-opiate receptors in the striata of IDPN-treated rats. These findings are similar to those seen in the brains of patients with Huntington's disease. Further studies are needed to clarify the relationship of these findings to the phenomenology of the IDPN-induced dyskinetic abnormalities.
长期给予亚氨基二丙腈（IDPN）会导致一种持续性行为综合征，该综合征包括多动、垂直性颈部运动障碍和头部侧向抽搐。D-丙氨酸-D-亮氨酸-脑啡肽结合显示，经IDPN处理的大鼠纹状体中δ-阿片受体数量减少了26%，但亲和力没有变化。这些发现与亨廷顿舞蹈症患者大脑中的情况相似。需要进一步研究来阐明这些发现与IDPN诱导的运动障碍异常现象学之间的关系。
