Rabaan Ali A, Aljeldah Mohammed, Shammari Basim R Al, Alsubki Roua A, Alotaibi Jawaher, Alhashem Yousef N, Alali Neda A, Sulaiman Tarek, Alsalem Zainab, Bajunaid Huda A, Garout Mohammed, Alsaffar Heba A, Almuthree Souad A, Hudhaiah Doha, Alzaher Azhar M, Alshaikh Fatimah A, Alshengeti Amer, Najim Mustafa A, Farahat Ramadan Abdelmoez, Mohapatra Ranjan K
Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran 31311, Saudi Arabia.
College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia.
Microorganisms. 2023 Jan 30;11(2):341. doi: 10.3390/microorganisms11020341.
The scale at which the SARS-CoV-2/COVID-19 pandemic has spread remains enormous. Provided the genetic makeup of the virus and humans is readily available, the quest for knowing the mechanism and epidemiology continues to prevail across the entire scientific community. Several aspects, including immunology, molecular biology, and host-pathogen interaction, are continuously being dug into for preparing the human race for future pandemics. The exact reasons for vast differences in symptoms, pathophysiological implications of COVID-infections, and mortality differences remain elusive. Hence, researchers are also looking beyond traditional genomics, proteomics, and transcriptomics approach, especially entrusting the environmental regulation of the genetic landscape of COVID-human interactions. In line with these questions lies a critical process called epigenetics. The epigenetic perturbations in both host and parasites are a matter of great interest to unravel the disparities in COVID-19 mortalities and pathology. This review provides a deeper insight into current research on the epigenetic landscape of SARS-CoV-2 infection in humans and potential targets for augmenting the ongoing investigation. It also explores the potential targets, pathways, and networks associated with the epigenetic regulation of processes involved in SARS-CoV-2 pathology.
严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）/冠状病毒病（COVID-19）大流行的传播规模仍然巨大。鉴于病毒和人类的基因组成易于获取，整个科学界对了解其机制和流行病学的探索仍在继续。包括免疫学、分子生物学和宿主-病原体相互作用在内的几个方面正在不断深入研究，以便让人类为未来的大流行做好准备。COVID-19感染症状存在巨大差异的确切原因、病理生理影响以及死亡率差异仍然难以捉摸。因此，研究人员也在超越传统的基因组学、蛋白质组学和转录组学方法，尤其关注COVID-19与人类相互作用的基因格局的环境调控。与这些问题相关的是一个关键过程，即表观遗传学。宿主和病原体中的表观遗传扰动是解开COVID-19死亡率和病理学差异的重要研究方向。本综述深入探讨了当前关于人类SARS-CoV-2感染表观遗传格局的研究以及加强正在进行的调查的潜在靶点。它还探讨了与SARS-CoV-2病理学相关过程的表观遗传调控的潜在靶点、途径和网络。
