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研究. 的综合植物化学和抗溃疡性结肠炎作用。

Study on the Comprehensive Phytochemicals and the Anti-Ulcerative Colitis Effect of .

机构信息

School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.

Research Center of Natural Drugs, Jilin University, Changchun 130021, China.

出版信息

Molecules. 2023 Feb 4;28(4):1526. doi: 10.3390/molecules28041526.

DOI:10.3390/molecules28041526
PMID:36838515
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9964537/
Abstract

BACKGROUND

is a traditional medicinal plant that is widely used in folk medicine because of its diverse biological activities, particularly its anti-inflammatory effects. However, the alleviation effect of SP on ulcerative colitis (UC) has not yet been realized.

PURPOSE

To investigate the chemical composition and therapeutic effect of SP extract against UC.

METHODS

First, qualitative and quantitative analysis of SP 75% ethanol extract was performed by UPLC-Q/TOF-MS. Second, a dextran sodium sulfate (DSS) model of UC mice was developed to study the effects of SP on the symptoms, inflammatory factors, oxidative stress indexes and colon histopathology. Third, an integration of network pharmacology with metabolomics was performed to investigate the key metabolites, biological targets and metabolisms closely related to the effect of SP.

RESULTS

From the SP ethanol extract, 149 compounds were identified qualitatively and 20 were determined quantitatively. The SP could dose-dependently decrease the DAI score, spleen coefficient and the levels of TNF-α, IL-6, iNOS, MPO and MDA; increase the colon length, GSH level and SOD activity; and protect the intestinal barrier in the UC mice. Moreover, 10 metabolite biomarkers,18 targets and 5 metabolisms were found to play crucial roles in the treatment of UC with SP.

CONCLUSIONS

SP 75% ethanol extract could effectively alleviate the progression of UC and, therefore, could be classified as a novel natural treatment for UC.

摘要

背景

是一种传统的药用植物，由于其具有多种生物活性，特别是抗炎作用，在民间医学中被广泛应用。然而，SP 对溃疡性结肠炎 (UC) 的缓解作用尚未得到证实。

目的

研究 SP 提取物对溃疡性结肠炎的化学组成和治疗作用。

方法

首先，通过 UPLC-Q/TOF-MS 对 SP75%乙醇提取物进行定性和定量分析。其次，建立葡聚糖硫酸钠 (DSS) 诱导的 UC 小鼠模型，研究 SP 对 UC 症状、炎症因子、氧化应激指标和结肠组织病理学的影响。再次，采用网络药理学与代谢组学相结合的方法，研究与 SP 作用密切相关的关键代谢物、生物靶标和代谢途径。

结果

从 SP 乙醇提取物中定性鉴定了 149 种化合物，定量测定了 20 种化合物。SP 可剂量依赖性地降低 DAI 评分、脾系数以及 TNF-α、IL-6、iNOS、MPO 和 MDA 的水平；增加结肠长度、GSH 水平和 SOD 活性；并保护 UC 小鼠的肠道屏障。此外，发现了 10 种代谢物生物标志物、18 个靶标和 5 种代谢途径在 SP 治疗 UC 中发挥关键作用。

结论

SP75%乙醇提取物能有效缓解 UC 的进展，因此可将其归类为治疗 UC 的新型天然药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e43/9964537/b48e1872eb88/molecules-28-01526-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e43/9964537/344e6061afd0/molecules-28-01526-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e43/9964537/4abd5e57031c/molecules-28-01526-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e43/9964537/ea0602320f0a/molecules-28-01526-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e43/9964537/a44722ea1342/molecules-28-01526-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e43/9964537/65dfb711eab8/molecules-28-01526-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e43/9964537/394526b1b2d1/molecules-28-01526-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e43/9964537/65304017d207/molecules-28-01526-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e43/9964537/fcb2854746c7/molecules-28-01526-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e43/9964537/8bd2245e0003/molecules-28-01526-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e43/9964537/b48e1872eb88/molecules-28-01526-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e43/9964537/344e6061afd0/molecules-28-01526-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e43/9964537/d7e2ec25e252/molecules-28-01526-g002a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e43/9964537/f1333edeab27/molecules-28-01526-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e43/9964537/4abd5e57031c/molecules-28-01526-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e43/9964537/ea0602320f0a/molecules-28-01526-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e43/9964537/a44722ea1342/molecules-28-01526-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e43/9964537/65dfb711eab8/molecules-28-01526-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e43/9964537/394526b1b2d1/molecules-28-01526-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e43/9964537/65304017d207/molecules-28-01526-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e43/9964537/fcb2854746c7/molecules-28-01526-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e43/9964537/8bd2245e0003/molecules-28-01526-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e43/9964537/b48e1872eb88/molecules-28-01526-g012.jpg

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