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芸香柚皮苷：一种具有强大细胞毒性和抗癌特性的有前景的类黄酮：分子机制与治疗潜力

Rhoifolin: A promising flavonoid with potent cytotoxic and anticancer properties: molecular mechanisms and therapeutic potential.

作者信息

Kiliç Ceyda Sibel, Kisla Mehmet Murat, Amasya Gülin, Sengel-Türk Ceyda Tugba, Alagöz Zeynep Ates, Gençler Özkan Ayse Mine, Ates Ilker, Gümüsok Safa, Herrera-Bravo Jesús, Sharifi-Rad Javad, Calina Daniela

机构信息

Department of Pharmaceutical Botany, Faculty of Pharmacy, Ankara University, Tandogan, Türkiye.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandogan, Türkiye.

出版信息

EXCLI J. 2025 Feb 25;24:289-320. doi: 10.17179/excli2024-7836. eCollection 2025.

DOI:10.17179/excli2024-7836
PMID:40071026
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11895061/
Abstract

Rhoifolin is a flavonoid found in various plant species, especially within the Rutaceae family, and is considered a dietary component due to its presence in edible plants. Its bioactive properties, such as cytotoxic and anticancer activities, have gained significant attention. This review aims to highlight the general properties and diverse bioactivities of rhoifolin, with a particular focus on its cytotoxic and anticancer effects. This is based on a comprehensive literature search, focusing on the presence of rhoifolin in different plant species and its biological activities, particularly its anticancer properties. Rhoifolin is widely distributed in the plant kingdom, especially in species. It exhibits a variety of bioactivities, including strong cytotoxic and anticancer effects. Recent studies have shown that rhoifolin can induce apoptosis and inhibit cancer cell proliferation, making it a promising candidate for anticancer therapies. Rhoifolin's diverse bioactivities, particularly its cytotoxic and anticancer properties, position it as a potential therapeutic agent. Further detailed investigations into its molecular mechanisms and well-designed clinical studies are needed to fully understand and utilize its therapeutic potential. See also the graphical abstract(Fig. 1).

摘要

芸香柚皮苷是一种存在于多种植物物种中的黄酮类化合物，特别是在芸香科植物中，由于其存在于可食用植物中，被认为是一种膳食成分。其生物活性特性，如细胞毒性和抗癌活性，已受到广泛关注。本综述旨在突出芸香柚皮苷的一般特性和多样的生物活性，特别关注其细胞毒性和抗癌作用。这是基于全面的文献检索，重点关注芸香柚皮苷在不同植物物种中的存在及其生物活性，特别是其抗癌特性。芸香柚皮苷在植物界广泛分布，特别是在某些物种中。它表现出多种生物活性，包括强烈的细胞毒性和抗癌作用。最近的研究表明，芸香柚皮苷可诱导细胞凋亡并抑制癌细胞增殖，使其成为抗癌治疗的有前途的候选药物。芸香柚皮苷多样的生物活性，特别是其细胞毒性和抗癌特性，使其成为一种潜在的治疗剂。需要对其分子机制进行进一步详细研究和精心设计的临床研究，以充分了解和利用其治疗潜力。另见图1（图形摘要）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb3d/11895061/cafe7ba6e778/EXCLI-24-289-g-007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb3d/11895061/fc906db447bc/EXCLI-24-289-t-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb3d/11895061/c758837900a3/EXCLI-24-289-t-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb3d/11895061/83d617890057/EXCLI-24-289-t-003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb3d/11895061/dea0a7abf9ed/EXCLI-24-289-t-004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb3d/11895061/b87ae07ee2fa/EXCLI-24-289-t-005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb3d/11895061/faacddc48362/EXCLI-24-289-t-006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb3d/11895061/de1bf73048ab/EXCLI-24-289-g-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb3d/11895061/fec09844eed5/EXCLI-24-289-g-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb3d/11895061/18baa2fabe44/EXCLI-24-289-g-003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb3d/11895061/b71cbd32c4cb/EXCLI-24-289-g-004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb3d/11895061/28d6b2ee6191/EXCLI-24-289-g-005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb3d/11895061/51a181c531f1/EXCLI-24-289-g-006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb3d/11895061/cafe7ba6e778/EXCLI-24-289-g-007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb3d/11895061/fc906db447bc/EXCLI-24-289-t-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb3d/11895061/c758837900a3/EXCLI-24-289-t-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb3d/11895061/83d617890057/EXCLI-24-289-t-003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb3d/11895061/dea0a7abf9ed/EXCLI-24-289-t-004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb3d/11895061/b87ae07ee2fa/EXCLI-24-289-t-005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb3d/11895061/faacddc48362/EXCLI-24-289-t-006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb3d/11895061/de1bf73048ab/EXCLI-24-289-g-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb3d/11895061/fec09844eed5/EXCLI-24-289-g-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb3d/11895061/18baa2fabe44/EXCLI-24-289-g-003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb3d/11895061/b71cbd32c4cb/EXCLI-24-289-g-004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb3d/11895061/28d6b2ee6191/EXCLI-24-289-g-005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb3d/11895061/51a181c531f1/EXCLI-24-289-g-006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb3d/11895061/cafe7ba6e778/EXCLI-24-289-g-007.jpg

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