Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China.
Molecules. 2023 Feb 8;28(4):1650. doi: 10.3390/molecules28041650.
A Lewis acid-promoted annulation of azadienes and cyclobutamines was developed. This reaction proceeded through Michael addition and ring-expansion cascade, affording the corresponding nitrogen-containing medium-sized rings with a broad scope in moderate to high yields. The catalytic asymmetric version of this reaction has also been explored using a chiral base.
发展了一种路易斯酸促进的氮杂二烯和环丁胺的环化反应。该反应通过迈克尔加成和环扩张级联进行，以中等至高产率得到相应的含氮中环。还使用手性碱探索了该反应的催化不对称版本。
