厚朴酚，一种类似新木脂素的药物，可抑制猪流行性腹泻病毒在培养细胞中的复制。
Magnolol, a Neolignan-like Drug, Inhibits Porcine Epidemic Diarrhea Virus Replication in Cultured Cells.
作者信息
Wang Xiaoting, Chen Bingqing, Yu Ruisong, Si Fusheng, Xie Chunfang, Li Zhen, Dong Shijuan, Zhang Daojing
机构信息
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology (ECUST), Shanghai 200237, China.
Shanghai Key Laboratory of Agricultural Genetics and Breeding, Shanghai Engineering Research Center of Breeding Pig, Institute of Animal Husbandry and Veterinary Science, Shanghai Academy of Agricultural Sciences (SAAS), Shanghai 201106, China.
出版信息
Pathogens. 2023 Feb 6;12(2):263. doi: 10.3390/pathogens12020263.
Porcine epidemic diarrhea virus (PEDV) is a destructive pathogen that continues to adversely affect the swine industry worldwide due to a current lack of vaccines and drugs capable of effective disease control. In the present study, the neolignan-like drug, magnolol (MAG), was tested for its ability to inhibit a Vero-cell adapted PEDV strain DR13. Our data revealed that MAG exhibited anti-PEDV activity in vitro, with IC and CC values of 28.21 μM and 57.28 μM, respectively. MAG was an efficient inhibitor of viral replication, and repression of viral proliferation was strongest when the host cells were exposed to MAG and the virus at the same time. Although our data indicate that MAG has the potential to be a useful PEDV control agent, in vivo testing of the drug, using animal hosts, is required.
猪流行性腹泻病毒（PEDV）是一种具有破坏性的病原体，由于目前缺乏能够有效控制疾病的疫苗和药物，它继续对全球养猪业产生不利影响。在本研究中，对新木脂素类药物厚朴酚（MAG）抑制Vero细胞适应的PEDV毒株DR13的能力进行了测试。我们的数据显示，MAG在体外表现出抗PEDV活性，其IC和CC值分别为28.21μM和57.28μM。MAG是病毒复制的有效抑制剂，当宿主细胞同时暴露于MAG和病毒时，病毒增殖的抑制作用最强。虽然我们的数据表明MAG有可能成为一种有用的PEDV控制剂，但需要使用动物宿主对该药物进行体内测试。
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