College of Veterinary Medicine, National Reference Laboratory of Veterinary Drug Residues (HZAU) and MOA Key Laboratory for the Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, People's Republic of China.
Center for Veterinary Sciences, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
Vet Q. 2024 Dec;44(1):1-49. doi: 10.1080/01652176.2024.2421299. Epub 2024 Nov 1.
The porcine enteric coronaviruses (PECs) currently reported include porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), transmissible gastroenteritis virus (TGEV), and swine acute diarrhea syndrome coronavirus (SADS-CoV). In the absence of effective treatment, they can cause similar clinical characteristics including weight loss, sleepiness, vomiting, anorexia and fatal diarrhea in neonatal piglets, resulting in significant economic losses to the global pig industry. Although many studies on drugs for treating and combating PECs have been issued. There are still no specific drug targeting PECs and used in clinical production. Therefore, it is necessary to sort out and summarize the research on the treatment and anti PECs drugs, and further development of low toxicity and high efficiency drugs is needed. Here, we review the latest progress of anti PECs drugs, focus on the mechanism of anti PECs reaction of drug components, and try to clarify new strategies for effective control and elimination of PECs. These comprehensive and profound insights will help to further investigate, prevent and control the transmission of PECs infection.
目前报道的猪肠道冠状病毒（PECs）包括猪流行性腹泻病毒（PEDV）、猪德尔塔冠状病毒（PDCoV）、传染性胃肠炎病毒（TGEV）和猪急性腹泻综合征冠状病毒（SADS-CoV）。在缺乏有效治疗方法的情况下，它们会导致新生仔猪出现类似的临床特征，包括体重减轻、嗜睡、呕吐、厌食和致命性腹泻，给全球养猪业造成重大经济损失。尽管已经有许多关于治疗和防治 PECs 的药物研究发表，但目前仍没有针对 PECs 的特效药物用于临床生产。因此，有必要对治疗和抗 PECs 药物的研究进行梳理和总结，并进一步开发低毒高效的药物。在这里，我们综述了抗 PECs 药物的最新研究进展，重点介绍了药物成分抗 PECs 反应的机制，并试图阐明有效控制和消除 PECs 的新策略。这些全面而深刻的见解将有助于进一步研究、预防和控制 PECs 感染的传播。
