Brandão Yara de Oliveira, Molento Marcelo Beltrão
Graduate Program in Microbiology, Parasitology, Pathology, Laboratory of Veterinary Clinical Parasitology, Federal University of Paraná, Curitiba 80035-050, PR, Brazil.
Pathogens. 2023 Feb 11;12(2):299. doi: 10.3390/pathogens12020299.
Interest in host epigenetic changes during apicomplexan infections increased in the last decade, mainly due to the emergence of new therapies directed to these alterations. This review aims to carry out a bibliometric analysis of the publications related to host epigenetic changes during apicomplexan infections and to summarize the main studied pathways in this context, pointing out those that represent putative drug targets. We used four databases for the article search. After screening, 116 studies were included. The bibliometric analysis revealed that the USA and China had the highest number of relevant publications. The evaluation of the selected studies revealed that was considered in most of the studies, non-coding RNA was the most frequently reported epigenetic event, and host defense was the most explored pathway. These findings were reinforced by an analysis of the co-occurrence of keywords. Even though we present putative targets for repurposing epidrugs and ncRNA-based drugs in apicomplexan infections, we understand that more detailed knowledge of the hosts' epigenetic pathways is still needed before establishing a definitive drug target.
在过去十年中，人们对顶复门寄生虫感染期间宿主表观遗传变化的兴趣有所增加，这主要归因于针对这些改变的新疗法的出现。本综述旨在对与顶复门寄生虫感染期间宿主表观遗传变化相关的出版物进行文献计量分析，并总结在此背景下主要研究的途径，指出那些代表潜在药物靶点的途径。我们使用了四个数据库进行文献检索。经过筛选，纳入了116项研究。文献计量分析表明，美国和中国的相关出版物数量最多。对所选研究的评估显示，大多数研究都考虑了[此处原文缺失具体内容]，非编码RNA是最常报道的表观遗传事件，宿主防御是研究最多的途径。对关键词共现的分析进一步证实了这些发现。尽管我们提出了在顶复门寄生虫感染中重新利用表观遗传药物和基于非编码RNA的药物的潜在靶点，但我们明白，在确定最终的药物靶点之前，仍需要对宿主的表观遗传途径有更详细的了解。
