Ramirez Ramirez Aína Danaisa, de Jesus Myrela Conceição Santos, Rossit Júlia, Reis Nathália Faria, Santos-Filho Marcelo Cerilo, Sudré Adriana Pittella, de Oliveira-Ferreira Joseli, Baptista Andrea Regina de Souza, Storti-Melo Luciane Moreno, Machado Ricardo Luiz Dantas
Center for Microorganisms' Investigation, Department of Microbiology and Parasitology, Biomedical Institute, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.
Laboratory of Molecular Genetics and Biotechnology, Department of Biology, Center for Biological and Health Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil.
Heliyon. 2022 Apr 22;8(4):e09318. doi: 10.1016/j.heliyon.2022.e09318. eCollection 2022 Apr.
Toll-like receptors (TLRs) play a key role in the induced immune response in malaria. Although the potential roles of TLRs have been described, it is necessary to elucidate which of these receptors may actually have an impact on the immunopathogenesis of the disease. This article performed a meta-analysis adhered to the PRISMA statement on TLRs studied in malaria by and and its impact on susceptibility and pathogenesis during malaria. A search of the literature was undertaken in PubMed, LILACS and SciELO published until June 30th, 2020. The risk of bias was calculated using the Joanna Briggs Institute's Critical Review Checklist. Later, based on the inclusion and/or exclusion criteria, 17 out of 296 articles were harvested for this systematic review, the meta-analysis included studies incorporating 6,747 cases and 8,983 controls. The results showed that only TLR1, TLR9 and TLR4 receptors were associated with parasitemia, TLR2 and TLR6 were related with severity and none TLR was correlated with susceptibility. The data described here should be taken with caution, since the current evidence is limited and inconsistent. More studies are needed given that the results may change depending on the region and genetic background of the populations.
Toll样受体（TLRs）在疟疾诱导的免疫反应中起关键作用。尽管已经描述了TLRs的潜在作用，但有必要阐明这些受体中哪些可能实际上对该疾病的免疫发病机制有影响。本文按照PRISMA声明对在疟疾中研究的TLRs及其对疟疾易感性和发病机制的影响进行了荟萃分析。在截至2020年6月30日发表在PubMed、LILACS和SciELO上的文献中进行了检索。使用乔安娜·布里格斯研究所的批判性评价清单计算偏倚风险。随后，根据纳入和/或排除标准，从296篇文章中筛选出17篇用于本系统评价，荟萃分析纳入了涉及6747例病例和8983例对照的研究。结果表明，只有TLR1、TLR9和TLR4受体与寄生虫血症相关，TLR2和TLR6与严重程度相关，没有TLR与易感性相关。鉴于目前的证据有限且不一致，此处描述的数据应谨慎对待。鉴于结果可能因人群的地区和遗传背景而异，需要更多的研究。
