Yang Hyun Seok, Kim Dong Wuk
BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit, Vessel-Organ Interaction Research Center (VOICE, MRC), Research Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University, Daegu 41566, Republic of Korea.
Pharmaceutics. 2023 Jan 18;15(2):316. doi: 10.3390/pharmaceutics15020316.
Semisolid extrusion (SSE) three-dimensional (3D) printing uses drug-loaded paste for the printing process, which is capable of constructing intricate 3D structures. This research presents a unique method for fabricating gastro-floating tablets (GFT) using SSE. Paste-loaded famotidine with a matrix made of hydroxypropyl methylcellulose (HPMC) were prepared. Nine 3D printed tablets were developed with different HPMC concentrations and infill percentages and evaluated to determine their physicochemical properties, content uniformity, dissolution, and floating duration. The crystallinity of the drug remained unchanged throughout the process. Dissolution profiles demonstrated the correlation between the HPMC concentration/infill percentage and drug release behavior over 10 h. All the fabricated GFTs could float for 10 h and the Korsmeyer-Peppas model described the dissolution kinetics as combination of non-Fickian or anomalous transport mechanisms. The results of this study provided insight into the predictability of SSE 3D printability, which uses hydro-alcoholic gel-API blend materials for GFTs by controlling traditional pharmaceutical excipients and infill percentages. SSE 3D printing could be an effective blueprint for producing controlled-release GFTs, with the additional benefits of simplicity and versatility over conventional methods.
半固体挤出（SSE）三维（3D）打印在打印过程中使用载药糊剂，能够构建复杂的三维结构。本研究提出了一种使用SSE制造胃漂浮片（GFT）的独特方法。制备了含法莫替丁糊剂和由羟丙基甲基纤维素（HPMC）制成的基质。开发了九种具有不同HPMC浓度和填充率的3D打印片剂，并对其进行评估以确定其物理化学性质、含量均匀度、溶出度和漂浮持续时间。在整个过程中，药物的结晶度保持不变。溶出曲线表明了HPMC浓度/填充率与10小时内药物释放行为之间的相关性。所有制造的GFT都能漂浮10小时，Korsmeyer-Peppas模型将溶出动力学描述为非Fickian或异常转运机制的组合。本研究结果为SSE 3D打印性的可预测性提供了见解，该方法通过控制传统药用辅料和填充率，将水醇凝胶-活性药物成分混合材料用于GFT。SSE 3D打印可能是生产控释GFT的有效蓝图，与传统方法相比，还具有简单性和通用性等额外优点。
