Giri Bhupendra Raj, Song Eon Soo, Kwon Jaewook, Lee Ju-Hyun, Park Jun-Bom, Kim Dong Wuk
College of Pharmacy & Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Korea.
College of Pharmacy, Sahmyook University, Seoul 01795, Korea.
Pharmaceutics. 2020 Jan 17;12(1):77. doi: 10.3390/pharmaceutics12010077.
This work presents a novel approach for producing gastro-retentive floating tablets (GRFT) by coupling hot-melt extrusion (HME) and fused deposition three-dimensional printing (3DP). Filaments containing theophylline (THEO) within a hydroxypropyl cellulose (HPC) matrix were prepared using HME. 3DP tablets with different infill percentages and shell thickness were developed and evaluated to determine their drug content, floating behavior, dissolution, and physicochemical properties. The dissolution studies revealed a relationship between the infill percentage/shell thickness and the drug release behavior of the 3DP tablets. All the developed GRFTs possessed the ability to float for 10 h and exhibited zero-order release kinetics. The drug release could be described by the Peppas-Sahlin model, as a combination of Fickian diffusion and swelling mechanism. Drug crystallinity was found unaltered throughout the process. 3DP coupled with HME, could be an effective blueprint to produce controlled-release GRFTs, providing the advantage of simplicity and versatility compared to the conventional methods.
这项工作提出了一种通过结合热熔挤出（HME）和熔融沉积三维打印（3DP）来制备胃滞留漂浮片（GRFT）的新方法。使用HME制备了在羟丙基纤维素（HPC）基质中含有茶碱（THEO）的长丝。开发并评估了具有不同填充百分比和壳厚度的3DP片剂，以确定它们的药物含量、漂浮行为、溶出度和理化性质。溶出度研究揭示了填充百分比/壳厚度与3DP片剂的药物释放行为之间的关系。所有开发的GRFT都具有漂浮10小时的能力，并表现出零级释放动力学。药物释放可以用Peppas-Sahlin模型来描述，它是菲克扩散和溶胀机制的组合。在整个过程中发现药物结晶度未改变。与传统方法相比，3DP与HME相结合可能是生产控释GRFT的有效方案，具有简单和通用的优点。
