Protasoni Margherita, Serrano Manuel
Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain.
Catalan Institution for Research and Advanced Studies (ICREA), 08010 Barcelona, Spain.
Pharmaceutics. 2023 Jan 20;15(2):352. doi: 10.3390/pharmaceutics15020352.
Ageing is accompanied by a progressive impairment of cellular function and a systemic deterioration of tissues and organs, resulting in increased vulnerability to multiple diseases. Here, we review the interplay between two hallmarks of ageing, namely, mitochondrial dysfunction and cellular senescence. The targeting of specific mitochondrial features in senescent cells has the potential of delaying or even reverting the ageing process. A deeper and more comprehensive understanding of mitochondrial biology in senescent cells is necessary to effectively face this challenge. Here, we discuss the main alterations in mitochondrial functions and structure in both ageing and cellular senescence, highlighting the differences and similarities between the two processes. Moreover, we describe the treatments available to target these pathways and speculate on possible future directions of anti-ageing and anti-senescence therapies targeting mitochondria.
衰老伴随着细胞功能的进行性损伤以及组织和器官的全身性衰退，导致对多种疾病的易感性增加。在此，我们综述衰老的两个标志——线粒体功能障碍和细胞衰老之间的相互作用。针对衰老细胞中特定的线粒体特征具有延缓甚至逆转衰老过程的潜力。为了有效应对这一挑战，有必要更深入、更全面地了解衰老细胞中的线粒体生物学。在此，我们讨论衰老和细胞衰老中线粒体功能和结构的主要变化，强调这两个过程之间的异同。此外，我们描述了针对这些途径的现有治疗方法，并推测了针对线粒体的抗衰老和抗衰老疗法未来可能的发展方向。
