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鞘内注射血管活性肠肽主要调节大鼠对皮肤热刺激的脊髓反射兴奋性。

Intrathecal vasoactive intestinal polypeptide modulates spinal reflex excitability primarily to cutaneous thermal stimuli in rats.

作者信息

Wiesenfeld-Hallin Z

机构信息

Department of Clinical Neurophysiology and Physiology, Karolinska Institute, Huddinge University Hospital, Sweden.

出版信息

Neurosci Lett. 1987 Oct 5;80(3):293-7. doi: 10.1016/0304-3940(87)90470-8.

DOI:10.1016/0304-3940(87)90470-8
PMID:3683984
Abstract

The effect of intrathecally (i.t.) injected vasoactive intestinal polypeptide (VIP) on spinal nocifensive flexor reflex excitability was examined in decerebrate, spinalized, unanesthetized rats. The hamstring reflex was evoked by intense cutaneous mechanical or thermal stimulation of the ipsilateral foot. I.t. VIP increased the excitability of the spinal cord to thermal much more than to mechanical stimuli. It is suggested that this neuropeptide is released by thermosensitive cutaneous afferents that respond poorly to mechanical stimuli.

摘要

在去大脑、脊髓横断、未麻醉的大鼠中，研究了鞘内注射血管活性肠肽（VIP）对脊髓伤害性屈肌反射兴奋性的影响。通过对同侧足部进行强烈的皮肤机械或热刺激来诱发绳肌反射。鞘内注射VIP使脊髓对热刺激的兴奋性增加程度远大于对机械刺激的增加程度。提示这种神经肽由对机械刺激反应较差的热敏性皮肤传入神经释放。

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Intrathecal vasoactive intestinal polypeptide modulates spinal reflex excitability primarily to cutaneous thermal stimuli in rats.鞘内注射血管活性肠肽主要调节大鼠对皮肤热刺激的脊髓反射兴奋性。
Neurosci Lett. 1987 Oct 5;80(3):293-7. doi: 10.1016/0304-3940(87)90470-8.
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引用本文的文献

1
Intrathecal galanin at low doses increases spinal reflex excitability in rats more to thermal than mechanical stimuli.低剂量鞘内注射甘丙肽对大鼠脊髓反射兴奋性的增强作用，对热刺激的反应比对机械刺激的反应更明显。
Exp Brain Res. 1988;71(3):663-6. doi: 10.1007/BF00248760.