Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virginia, USA.
Department of Large Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virginia, USA.
J Vet Intern Med. 2023 Mar;37(2):718-727. doi: 10.1111/jvim.16663. Epub 2023 Feb 24.
Acetaminophen has been evaluated in horses for treatment of musculoskeletal pain but not as an antipyretic.
To determine the pharmacokinetics and efficacy of acetaminophen compared to placebo and flunixin meglumine in adult horses with experimentally induced endotoxemia.
Eight university owned research horses with experimentally induced endotoxemia.
Randomized placebo controlled crossover study. Horses were treated with acetaminophen (30 mg/kg PO; APAP), flunixin meglumine (1.1 mg/kg, PO; FLU), and placebo (PO; PLAC) 2 hours after administration of LPS. Plasma APAP was analyzed via LC-MS/MS. Serial CBC, lactate, serum amyloid A, heart rate and rectal temperature were evaluated. Serum IL-1β, IL-6, IL-8, IL-10, and TNF-α were evaluated by an equine-specific multiplex assay.
Mean maximum plasma APAP concentration was 13.97 ± 2.74 μg/mL within 0.6 ± 0.3 hour after administration. At 4 and 6 hours after treatment, both APAP (P = <.001, P = .03, respectively) and FLU (P = .0045 and P < .001, respectively) had a significantly greater decrease in rectal temperature compared to placebo. FLU caused greater heart rate reduction than APAP at 4 and 6 hours (P = .004 and P = .04), and PLAC at 4 hours (P = .05) after treatment.
The pharmacokinetics of acetaminophen in endotoxemic horses differ from those reported by previous studies in healthy horses. Acetaminophen is an option for antipyresis in clinical cases, particularly when administration of traditional NSAIDs is contraindicated.
已评估乙酰氨基酚治疗马的肌肉骨骼疼痛，但尚未评估其作为解热药的效果。
确定与安慰剂和氟尼辛葡甲胺相比，乙酰氨基酚在患有实验性内毒素血症的成年马中的药代动力学和疗效。
8 匹患有实验性内毒素血症的大学拥有的研究用马。
随机安慰剂对照交叉研究。在给予 LPS 后 2 小时，马分别接受乙酰氨基酚（30mg/kg PO；APAP）、氟尼辛葡甲胺（1.1mg/kg，PO；FLU）和安慰剂（PO；PLAC）治疗。通过 LC-MS/MS 分析血浆中的 APAP。连续评估全血计数、乳酸、血清淀粉样蛋白 A、心率和直肠温度。通过马专用的多重分析评估血清 IL-1β、IL-6、IL-8、IL-10 和 TNF-α。
给药后 0.6±0.3 小时，APAP 的平均最大血浆浓度为 13.97±2.74μg/mL。治疗后 4 和 6 小时，APAP（P<.001，P=.03）和 FLU（P=.0045 和 P<.001）均比安慰剂显著降低直肠温度。FLU 在 4 和 6 小时（P=.004 和 P=.04）以及治疗后 4 小时（P=.05）时，与 APAP 相比，心率降低更明显。
内毒素血症马的乙酰氨基酚药代动力学与之前在健康马中报道的药代动力学不同。在临床病例中，特别是在传统 NSAIDs 禁忌时，乙酰氨基酚是一种退热选择。
