Department of Thoracic Surgery, Kars State Hospital, Yenişehir, Ismail Aytemiz Street 55, 36002, Kars, Turkey.
University of Health Sciences Turkey, Dr Suat Seren Chest Diseases and Chest Surgery Training and Research Hospital, Izmir, Turkey.
Updates Surg. 2023 Jun;75(4):1011-1017. doi: 10.1007/s13304-023-01473-z. Epub 2023 Feb 25.
Nodal metastasis status is an important parameter affecting the prognosis in lung cancer. Although surgical treatment is possible in most cases of N1 positive non-small cell lung cancer, this group of patients is clinically, radiologically and histologically heterogeneous. The aim of our study is to investigate the prognostic factors affecting survival in patients with pT1-2 N1 who underwent lung resection. From January 2010 to December 2019, patients who underwent lobectomy, bilobectomy or pneumonectomy for pT1-T2 N1 NSCLC in our center were included in the study. The preoperative, intraoperative and postoperative data of the patients were recorded by accessing the patient files and hospital records. The mean follow-up time was 39.8 months. The mean overall survival was 73.8 ± 3.6, and the mean disease-free survival was 67.5 ± 3.8. In multivariate analysis, age, N1 nodal metastasis pattern (occult vs obvious) and histology were found as independent variables affecting survival. In our study, age, histology, and clinical N1 status were found to be independent variables effective on overall survival.
淋巴结转移状态是影响肺癌预后的一个重要参数。虽然大多数 N1 阳性非小细胞肺癌患者都可以进行手术治疗，但这组患者在临床、影像学和组织学上存在异质性。我们的研究旨在探讨影响接受肺切除术的 pT1-2 N1 患者生存的预后因素。2010 年 1 月至 2019 年 12 月，我们中心对接受肺叶切除术、双肺叶切除术或全肺切除术治疗 pT1-T2N1NSCLC 的患者进行了研究。通过查阅患者档案和病历记录了患者的术前、术中及术后资料。平均随访时间为 39.8 个月。总的中位生存期为 73.8±3.6 个月，无病生存期的中位值为 67.5±3.8 个月。多因素分析发现，年龄、N1 淋巴结转移模式（隐匿性 vs 明显性）和组织学是影响生存的独立变量。在我们的研究中，年龄、组织学和临床 N1 状态被发现是影响总生存的独立变量。
