肌醇单磷酸酶在癌症中的新作用。
Emerging role of inositol monophosphatase in cancer.
作者信息
Chen Qian, Shen Liangfang, Li Shan
机构信息
Department of Oncology, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, China.
Department of Oncology, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, China.
出版信息
Biomed Pharmacother. 2023 May;161:114442. doi: 10.1016/j.biopha.2023.114442. Epub 2023 Feb 24.
Inositol monophosphatase (IMPase) is an enzyme with two homologs-IMPA1 and IMPA2-that is responsible for dephosphorylating myo-inositol monophosphate to generate myo-inositol. IMPase has been extensively studied in neuropsychiatric diseases and is regarded as a susceptibility gene. Recently, emerging evidence has implied that IMPase is linked to cancer development and progression and correlates with patient survival outcomes. Interestingly, whether it acts as a tumor-promoter or tumor-suppressor is inconsistent among different research studies. In this review, we summarize the latest findings on IMPase in cancer, focusing on exploring the underlying mechanisms for its pro- and anticancer roles. In addition, we discuss the potential methods of IMPase regulation in cancer cells and the possible approaches for IMPase intervention in clinical practice.
肌醇单磷酸酶（IMPase）是一种具有两个同源物IMPA1和IMPA2的酶，负责将肌醇单磷酸去磷酸化以生成肌醇。IMPase已在神经精神疾病中得到广泛研究，并被视为一种易感基因。最近，新出现的证据表明IMPase与癌症的发生和发展有关，并与患者的生存结果相关。有趣的是，在不同的研究中，它是作为肿瘤促进剂还是肿瘤抑制剂的作用并不一致。在这篇综述中，我们总结了关于IMPase在癌症方面的最新发现，重点探讨其促癌和抗癌作用的潜在机制。此外，我们还讨论了癌细胞中IMPase调控的潜在方法以及临床实践中IMPase干预的可能途径。
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