Guo Zhi-Peng, Chen Lei, Tang Li-Rong, Gao Yue, Chand Tara, Sen Zümrüt Duygu, Li Meng, Walter Martin, Wang Lihong, Liu Chun-Hong
Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China.
Beijing Hospital of Anding, Capital Medical University, Beijing 100088, China.
J Affect Disord. 2023 May 15;329:88-95. doi: 10.1016/j.jad.2023.02.083. Epub 2023 Feb 24.
To investigate the altered interhemispheric functional connectivity in the resting state in patients with recurrent major depressive disorder (MDD).
Voxel-mirrored homotopic connectivity (VMHC), a measure of the functional connectivity between any pair of symmetrical interhemispheric voxels, and pattern classification were examined in 41 recurrent MDD patients (22 during the depressive state and 19 during the remitted state) and 60 age, sex, and education level-matched healthy controls (HC) using resting-state functional magnetic resonance imaging (fMRI).
Compared with HC, the recurrent MDD patients exhibited decreased VMHC values in the bilateral fusiform, inferior occipital gyrus, posterior insula, precentral gyrus, precuneus, superior temporal gyrus, and thalamus. A significant negative correlation between the VMHC value of the bilateral posterior insula and illness duration in recurrent MDD was identified. Support vector machine (SVM) analysis showed that VMHC in the fusiform and posterior insula could be used to distinguish recurrent MDD patients from HC with a sensitivity and accuracy >0.6.
Our findings revealed a reduction in the resting-state brain activity across several neural networks in patients with recurrent MDD, including within the posterior insula. Lower VMHC values in the posterior insula were associated with longer illness duration, suggesting that impairment in interhemispheric synchronization within the salience network may be due to the accumulated pathology of depression and may contribute to future depression relapse. VMHC changes in the posterior insula may serve as a potential imaging marker to discriminate recurrent MDD patients from HC.
探讨复发性重度抑郁症（MDD）患者静息状态下半球间功能连接的改变。
使用静息态功能磁共振成像（fMRI），对41例复发性MDD患者（22例处于抑郁状态，19例处于缓解状态）和60名年龄、性别及教育水平相匹配的健康对照者（HC）进行体素镜像同伦连接（VMHC，一种测量任意一对对称半球间体素功能连接的指标）及模式分类检查。
与HC相比，复发性MDD患者在双侧梭状回、枕下回、岛叶后部、中央前回、楔前叶、颞上回和丘脑的VMHC值降低。复发性MDD患者双侧岛叶后部的VMHC值与病程之间存在显著负相关。支持向量机（SVM）分析表明，梭状回和岛叶后部的VMHC可用于区分复发性MDD患者与HC，敏感性和准确性>0.6。
我们的研究结果显示，复发性MDD患者在包括岛叶后部在内的多个神经网络中的静息态脑活动减少。岛叶后部较低的VMHC值与较长的病程相关，这表明突显网络内半球间同步受损可能是由于抑郁症累积的病理改变所致，且可能导致未来抑郁症复发。岛叶后部的VMHC变化可能作为一种潜在的影像学标志物，用于区分复发性MDD患者与HC。
