Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Breast Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Trends Cancer. 2023 May;9(5):381-396. doi: 10.1016/j.trecan.2023.02.001. Epub 2023 Feb 24.
Induction of cell death is inexorably linked with cancer therapy, but this can also initiate wound-healing processes that have been linked to cancer progression and therapeutic resistance. Here we describe the contribution of apoptosis and the lytic cell death pathways in the response to therapy (including chemotherapy and immunotherapy). We also discuss how necroptosis, pyroptosis, and ferroptosis function to promote tumor immunogenicity, along with emerging findings that these same forms of death can paradoxically contribute to immune suppression and tumor progression. Understanding the duality of cell death in cancer may allow for the development of therapeutics that shift the balance towards regression.
细胞死亡的诱导与癌症治疗是密不可分的，但这也可能引发与癌症进展和治疗耐药性相关的伤口愈合过程。在这里，我们描述了细胞凋亡和溶细胞死亡途径在治疗反应（包括化疗和免疫治疗）中的贡献。我们还讨论了细胞坏死、细胞焦亡和铁死亡如何促进肿瘤免疫原性，以及新发现这些相同的死亡形式可能矛盾地促进免疫抑制和肿瘤进展。了解癌症中细胞死亡的双重性可能有助于开发治疗方法，使平衡向消退方向转变。
