锥形束计算机断层扫描检查是否会增加口腔黏膜脱落细胞的微核频率？系统评价和荟萃分析。
Does cone-beam computed tomography examination increase the micronuclei frequency in the oral mucosa exfoliated cells? A systematic review and meta-analysis.
机构信息
Department of Oral & Maxillofacial Radiology, Beijing Stomatology Hospital, School of Stomatology, Capital Medical University, Tian Tan Xi Li No.4, Beijing, 100050, China.
Department of Stomatology, Aerospace Center Hospital, Beijing, China.
出版信息
BMC Oral Health. 2023 Feb 25;23(1):127. doi: 10.1186/s12903-023-02832-3.
OBJECTIVE
This systematic review (SR) with meta-analysis aimed to evaluate the frequency of micronuclei in the oral mucosa exfoliated cells after cone-beam computed tomography (CBCT) examination.
METHODS
We performed language-independent computer-assisted data searches using PubMed databases, Cochrane, Embase, Web of Science all databases, and Google Scholar. The literature on micronucleus (MN) frequency of clinical trials before and after CBCT examination was included. The frequency of MN in exfoliated cells of the human oral mucosa was the primary outcome of the study. All statistical analyses were performed with R (version 4.1.0), RStudio (version 2022.02.2 + 485) software, and Meta packages (version 5.2-0). Two reviewers independently assessed the quality of the included studies by the EPHPP (Effective Public Health Practice Project) Modified scale with minor modifications. The heterogeneity of the data was analyzed using I statistics, in which I > 50% was considered substantial heterogeneity.
RESULTS
A total of 559 articles were selected through the search strategy. After screening titles and abstracts, nine full-text manuscripts were assessed for eligibility, and six observational studies were included in the meta-analysis. The present study showed a significant increase in MN frequency of human oral mucosal exfoliated cells 10 days after CBCT examination compared to baseline (SMD = - 0.56, 95%-CI = - 0.99 ~ - 0.13, p = 0.01). Because of the high heterogeneity among the studies (I = 72%), after removing one study that was the main source of heterogeneity, excluding the study (I = 47%), the common-effect model was chosen, and the meta-analysis also showed that the frequency of MN in human oral mucosa exfoliated cells increased significantly 10 days after CBCT examination (SMD = - 0.35, 95%-CI = - 0.59 ~ - 0.11, p = 0.004).
CONCLUSION
This review suggested that CBCT examination increases the frequency of micronuclei in oral mucosal exfoliated cells.
目的
本系统评价（SR）结合荟萃分析旨在评估锥形束 CT（CBCT）检查后口腔黏膜脱落细胞中微核的频率。
方法
我们使用 PubMed 数据库、Cochrane、Embase、Web of Science 所有数据库和 Google Scholar 进行了独立于语言的计算机辅助数据搜索。纳入了关于 CBCT 检查前后临床试验中微核（MN）频率的文献。研究的主要结局是口腔黏膜脱落细胞中 MN 的频率。所有统计分析均使用 R（版本 4.1.0）、RStudio（版本 2022.02.2+485）软件和 Meta 包（版本 5.2-0）进行。两位评审员使用 EPHPP（有效公共卫生实践项目）改良量表，对纳入研究的质量进行了独立评估，该量表经过了轻微修改。使用 I 统计量分析数据的异质性，其中 I>50% 被认为存在显著异质性。
结果
通过搜索策略共选择了 559 篇文章。在筛选标题和摘要后，评估了 9 篇全文手稿的纳入资格，共有 6 项观察性研究纳入荟萃分析。本研究显示，与基线相比，CBCT 检查后 10 天口腔黏膜脱落细胞中的 MN 频率显著增加（SMD=-0.56，95%-CI=-0.99-0.13，p=0.01）。由于研究之间存在高度异质性（I=72%），在剔除一项是主要异质性来源的研究后，排除该研究（I=47%），选择了共同效应模型，荟萃分析也显示 CBCT 检查后 10 天口腔黏膜脱落细胞中的 MN 频率显著增加（SMD=-0.35，95%-CI=-0.59-0.11，p=0.004）。
结论
本综述表明，CBCT 检查会增加口腔黏膜脱落细胞中微核的频率。
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