Staab Julia, Vonhören Lara, Schwörer Harald, Meyer Thomas
Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Göttingen, Georg August University Göttingen, Waldweg 33, 37073, Göttingen, Germany.
Department of Paediatric Cardiology and Intensive Care Medicine, University Medical Center Göttingen, Georg August University, Göttingen, Germany.
Biopsychosoc Med. 2023 Feb 25;17(1):6. doi: 10.1186/s13030-023-00264-7.
Previous clinical studies have reported elevated levels of depressive symptoms in selected samples of patients with gastritis. The objective of this study was to examine the associations of specific biomarkers of inflammation expressed in mucosal tissue from the stomach with mood and anxiety symptoms in adult patients with upper gastrointestinal symptoms.
In this monocentric, observational study, a total of 32 study participants were included who were referred for a routine diagnostic upper endoscopic assessment based on the suspected clinical diagnosis of gastritis. All participants completed the Hospital Anxiety and Depression Scale (HADS) before undergoing gastroscopy. Immunohistochemical stainings from biopsy sections were performed to evaluate the expression level of nuclear factor kappa B (NF-κ B), myeloperoxidase (MPO) and inducible nitric oxide synthase (iNOS).
Our findings confirmed that nearly half of the study cohort (n = 13; 41%) displayed positive HADS depression scores above the clinically relevant cut-off level of ≥ 8. Regression models demonstrated that depressive symptoms were significantly and positively associated with the expression level of NF-κ B in biopsies from the upper gastrointestinal tract.
In summary, our study showed a significant association between NF-κ B expression and clinically relevant depressive symptoms in patients with gastritis, as assessed by a self-rated psychometric questionnaire. Further investigations are needed to confirm this relationship and to identify the pathophysiological mechanisms involved.
先前的临床研究报告称，在某些胃炎患者样本中，抑郁症状水平有所升高。本研究的目的是探讨胃黏膜组织中表达的特定炎症生物标志物与成年上消化道症状患者的情绪和焦虑症状之间的关联。
在这项单中心观察性研究中，共纳入了32名研究参与者，他们因疑似胃炎的临床诊断而被转诊进行常规诊断性上消化道内镜评估。所有参与者在接受胃镜检查前均完成了医院焦虑抑郁量表（HADS）。对活检切片进行免疫组织化学染色，以评估核因子κB（NF-κB）、髓过氧化物酶（MPO）和诱导型一氧化氮合酶（iNOS）的表达水平。
我们的研究结果证实，近一半的研究队列（n = 13；41%）的HADS抑郁评分呈阳性，高于临床相关的临界值≥8。回归模型表明，抑郁症状与上消化道活检中NF-κB的表达水平显著正相关。
总之，我们的研究表明，通过自评心理测量问卷评估，胃炎患者中NF-κB表达与临床相关抑郁症状之间存在显著关联。需要进一步研究来证实这种关系，并确定其中涉及的病理生理机制。
