Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Al. Prof. Hernâni Monteiro, 4200-319, Porto, Portugal,
Dig Dis Sci. 2014 Aug;59(8):1698-709. doi: 10.1007/s10620-014-3063-0. Epub 2014 Feb 22.
The systematic assessment of large population-based surveys addressing the prevalence of Helicobacter pylori infection may provide robust evidence for understanding the trends in the exposure to this major risk factor across settings with distinct patterns of gastric cancer variation. Our aim was to describe the prevalence of H. pylori infection in different countries and periods, through systematic review of the literature. We searched PubMed from inception up to September 2013 to identify original studies reporting on the prevalence of H. pylori, and only those evaluating samples with national coverage were included. We identified 37 eligible studies including data for 22 countries. The prevalences were higher in Central/South America and Asia, and at least two-fold higher in countries with high gastric cancer incidence. In most countries presenting data for different time periods, the prevalences were usually lower in the most recent surveys. However, there was little variation in settings where prevalences were already low. Among countries with high prevalence of H. pylori infection there is an ample scope for reducing its burden in the next decades, whereas further declines in settings with already low prevalences will require more intensive efforts.
系统评估大规模基于人群的调查，以确定幽门螺杆菌感染的流行率，可能为了解在胃癌变化模式不同的环境中接触这一主要危险因素的趋势提供有力的证据。我们的目的是通过文献系统回顾，描述不同国家和时期的幽门螺杆菌感染流行率。我们检索了 PubMed 从创建到 2013 年 9 月的数据，以确定报告幽门螺杆菌流行率的原始研究，并且只包括评估具有全国代表性样本的研究。我们共发现 37 项符合条件的研究，其中包括 22 个国家的数据。在中/南美洲和亚洲，幽门螺杆菌感染的流行率较高，而在胃癌发病率较高的国家，其流行率至少高出两倍。在大多数提供不同时期数据的国家中，最近的调查中流行率通常较低。但是，在流行率已经较低的地区，变化很小。在幽门螺杆菌感染流行率高的国家中，在未来几十年中，减少其负担的空间很大，而在流行率已经较低的地区进一步下降，则需要更密集的努力。
