Hart D E, Lane B C, Josephson J E, Tisdale R R, Gzik M, Leahy R, Dennis R
Contact Lens Research Foundation, Jericho, NY 11753.
Ophthalmology. 1987 Oct;94(10):1315-21. doi: 10.1016/s0161-6420(87)80018-0.
"Jelly-bump" deposits, which are composed mainly of lipids, on high water content, extended-wear hydrogel lenses, are a clinically significant problem of unknown etiology. The authors explored the effect of nutrition on the frequency of deposition of these jelly bumps. Forty-three patients were included in this masked case-control study from five contact lens practices in North America. Thirty patients were lipid-depositor cases and 13 were controls. Tear specimens were drawn and analyzed for potassium by atomic-absorption spectrophotometry. Detailed dietary histories were conducted and diet nutrient composition was computed. Patients with diminished tear-potassium concentrations have an increased risk of jelly-bump deposition. Elevated intake of protein, alcohol, and cholesterol also appeared to be correlated significantly with increased jelly-bump deposition. The authors found that diabetics and the use of diuretics, anticholinergics, sympathomimetics, were associated with tear-film potassium depletion and lipid deposit formation.
“果冻状凸起”沉积物主要由脂质组成，出现在高含水量的长戴型水凝胶镜片上，是一个病因不明但具有临床意义的问题。作者探讨了营养对这些果冻状凸起沉积频率的影响。这项双盲病例对照研究纳入了来自北美五家隐形眼镜诊所的43名患者。其中30例为脂质沉积病例，13例为对照。采集泪液标本，用原子吸收分光光度法分析钾含量。详细记录饮食史并计算饮食营养成分。泪液钾浓度降低的患者出现果冻状凸起沉积的风险增加。蛋白质、酒精和胆固醇摄入量的增加似乎也与果冻状凸起沉积的增加显著相关。作者发现，糖尿病患者以及使用利尿剂、抗胆碱能药物、拟交感神经药物与泪膜钾缺乏和脂质沉积物形成有关。
