Hart D E, Tidsale R R, Sack R A
Ophthalmology. 1986 Apr;93(4):495-503. doi: 10.1016/s0161-6420(86)33709-6.
"Jelly bump" deposits, common to high-water-content hydrogel extended-wear contact lenses, were shown to be composed primarily of lipids, with calcium an optional minor component. Extraction, separation, and analysis of deposited versus nondeposited regions of the same lenses reveals that lipids were restricted to the deposited regions of the lens, with a composition of long and intermediate chain cholesterol esters (possibly waxy esters) and triglycerides. This composition is independent of deposit size or individual depositor. Except for an elevated triglyceride level, the composition mirrors that of the tear lipid layer. Analysis of tear films of heavy and nondepositors, combined with clinical evidence, reveals that many depositors have a relatively decreased tear flow with some exhibiting an elevated tear-lipid fraction. A mechanism of deposition is proposed to require the local depletion of the aqueous tear layer stranding lipid on the lens surface, thereby creating a hydrophobic region suitable for further deposition. Deposition does not mechanistically involve tear film proteins, calcium, or microorganisms although they can, at times, be associated with the lipid deposit.
“果冻状隆起”沉积物是高含水量水凝胶长戴型隐形眼镜常见的现象，研究表明其主要成分是脂质，钙是一种可选的次要成分。对同一镜片的沉积区和未沉积区进行提取、分离和分析发现，脂质局限于镜片的沉积区，其成分包括长链和中链胆固醇酯（可能是蜡酯）以及甘油三酯。这种成分与沉积物大小或个体佩戴者无关。除了甘油三酯水平升高外，其成分与泪液脂质层相似。对重度沉积物形成者和非沉积物形成者的泪膜进行分析，并结合临床证据发现，许多沉积物形成者的泪液流量相对减少，有些还表现出泪液脂质比例升高。有人提出一种沉积机制，即泪液水层局部耗尽，使脂质滞留在镜片表面，从而形成一个适合进一步沉积的疏水区域。沉积机制并不涉及泪膜蛋白、钙或微生物，尽管它们有时可能与脂质沉积物有关。
