Fan Panhui, Wu Liwei, Wang Qing, Wang Yu, Luo Hongmei, Song Jingyuan, Yang Meihua, Yao Hui, Chen Shilin
Key Lab of Chinese Medicine Resources Conservation, State Administration of Traditional Chinese Medicine of the People's Republic of China, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China.
Key Lab of Chinese Medicine Resources Conservation, State Administration of Traditional Chinese Medicine of the People's Republic of China, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China; Engineering Research Center of Chinese Medicine Resources, Ministry of Education, Beijing 100193, China.
J Hazard Mater. 2023 May 15;450:131008. doi: 10.1016/j.jhazmat.2023.131008. Epub 2023 Feb 14.
Medicinal plants have a wide range of uses worldwide. However, the quality of medicinal plants is affected by severe cadmium pollution. Cadmium can reduce photosynthetic capacity, lead to plant growth retardation and oxidative stress, and affect secondary metabolism. Medicinal plants have complex mechanisms to cope with cadmium stress. On the one hand, an antioxidant system can effectively scavenge excess reactive oxygen species produced by cadmium stress. On the other hand, cadmium chelates are formed by chelating peptides and then sequestered through vacuolar compartmentalization. Cadmium has no specific transporter in plants and is generally transferred to plant tissues through competition for the transporters of divalent metal ions, such as zinc, iron, and manganese. In recent years, progress has been achieved in exploring the physiological mechanisms by which medicinal plants responding to cadmium stress. The exogenous regulation of cadmium accumulation in medicinal plants has been studied, and the aim is reducing the toxicity of cadmium. However, research into molecular mechanisms is still lagging. In this paper, we review the physiological and molecular mechanisms and regulatory networks of medicinal plants exposed to cadmium, providing a reference for the study on the responses of medicinal plants to cadmium stress.
药用植物在全球范围内有着广泛的用途。然而，药用植物的质量受到严重镉污染的影响。镉会降低光合能力，导致植物生长迟缓并引发氧化应激，还会影响次生代谢。药用植物具有应对镉胁迫的复杂机制。一方面，抗氧化系统能有效清除镉胁迫产生的过量活性氧。另一方面，镉螯合物通过螯合肽形成，然后通过液泡区室化进行隔离。镉在植物中没有特定的转运蛋白，通常通过竞争二价金属离子（如锌、铁和锰）的转运蛋白转移到植物组织中。近年来，在探索药用植物对镉胁迫响应的生理机制方面取得了进展。已经对药用植物中镉积累的外源调控进行了研究，目的是降低镉的毒性。然而，分子机制的研究仍然滞后。在本文中，我们综述了药用植物暴露于镉时的生理和分子机制以及调控网络，为研究药用植物对镉胁迫的响应提供参考。
