Zhang Yixuan, Liu Jianchao, Jing Chenyang, Lu Guanghua, Jiang Runren, Zheng Xiqiang, He Chao, Ji Wenliang
Key Laboratory of Integrated Regulation and Resources Development of Shallow Lakes of Ministry of Education, Hohai University, Nanjing 210098, China; College of Environment, Hohai University, Nanjing 210098, China.
Key Laboratory of Integrated Regulation and Resources Development of Shallow Lakes of Ministry of Education, Hohai University, Nanjing 210098, China; College of Environment, Hohai University, Nanjing 210098, China.
Ecotoxicol Environ Saf. 2023 Mar 15;253:114682. doi: 10.1016/j.ecoenv.2023.114682. Epub 2023 Feb 24.
Due to relatively lower toxicity, bisphenol S (BPS) has become an alternative to previously used bisphenol A. Nevertheless, the occurrence of BPS and its ecological impact have recently attracted increasing attentions because the toxicology effect of BPS with life cycle or multigenerational exposure on aquatic organisms remains questionable. Herein, Daphnia magna (D. magna) multigenerational bioassays spanning four generations (F0-F3) and single-generation recovery (F1 and F3) in clean water were used to investigate the ecotoxicology of variable chronic BPS exposure. For both assays, four kinds of life-history traits (i.e., survival, reproduction, growth and ecological behavior) were examined for each generation. After an 18-day exposure under concentration of 200 μg/L, the survival rate of D. magna was less than 15 % for the F2 generation, whereas all died for the F3 generation. With continuous exposure of four generations of D. magna at environmentally relevant concentrations of BPS (2 μg/L), inhibition of growth and development, prolonged sexual maturity, decreased offspring production and decreased swimming activity were observed for the F3 generation. In particular, it is difficult for D. magna to return to its normal level through a single-generation recovery in clean water in terms of reproductive function, ecological behavior and population health. Hence, multi-generational exposure to low concentrations of BPS can have adverse effects on population health of aquatic organisms with short breeding cycles, highlighting the necessity to assess the ecotoxicology of chronic BPS exposure for public health.
由于毒性相对较低，双酚S（BPS）已成为先前使用的双酚A的替代品。然而，BPS的出现及其生态影响最近引起了越来越多的关注，因为BPS在生命周期或多代暴露下对水生生物的毒理学效应仍存在疑问。在此，使用跨越四代（F0 - F3）的大型溞（D. magna）多代生物测定法以及在清洁水中的单代恢复（F1和F3）来研究不同慢性BPS暴露的生态毒理学。对于这两种测定法，每一代都检查了四种生活史特征（即生存、繁殖、生长和生态行为）。在200 μg/L浓度下暴露18天后，F2代大型溞的存活率低于15%，而F3代全部死亡。在与环境相关的BPS浓度（2 μg/L）下对大型溞进行连续四代暴露后，观察到F3代生长发育受到抑制、性成熟延长、后代产量减少以及游泳活动减少。特别是，就生殖功能、生态行为和种群健康而言，大型溞很难通过在清洁水中的单代恢复回到正常水平。因此，多代暴露于低浓度的BPS会对繁殖周期短的水生生物的种群健康产生不利影响，突出了评估慢性BPS暴露对公共卫生的生态毒理学的必要性。
