Salvi Sachin M, Aziz Hassan A, Dar Suhail, Singh Nakul, Hayden-Loreck Brandy, Singh Arun D
Sheffield Ocular Oncology Service, Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield, UK.
Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Ohio, USA.
Ocul Oncol Pathol. 2017 Jul;3(2):87-94. doi: 10.1159/000451001. Epub 2016 Oct 29.
The objective was to evaluate the relationship between the regression rate of ciliary body melanoma and choroidal melanoma after brachytherapy and chromosome 3 monosomy status.
We conducted a prospective and consecutive case series of patients who underwent biopsy and brachytherapy for ciliary/choroidal melanoma. Tumor biopsy performed at the time of radiation plaque placement was analyzed with fluorescence in situ hybridization to determine the percentage of tumor cells with chromosome 3 monosomy. The regression rate was calculated as the percent change in tumor height at months 3, 6, and 12. The relationship between regression rate and tumor location, initial tumor height, and chromosome 3 monosomy (percentage) was assessed by univariate linear regression (R version 3.1.0).
Of the 75 patients included in the study, 8 had ciliary body melanoma, and 67 were choroidal melanomas. The mean tumor height at the time of diagnosis was 5.2 mm (range: 1.90-13.00). The percentage composition of chromosome 3 monosomy ranged from 0-20% (n = 35) to 81-100% (n = 40). The regression of tumor height at months 3, 6, and 12 did not statistically correlate with tumor location (ciliary or choroidal), initial tumor height, or chromosome 3 monosomy (percentage).
The regression rate of choroidal melanoma following brachytherapy did not correlate with chromosome 3 monosomy status.
本研究旨在评估近距离放射治疗后睫状体黑色素瘤和脉络膜黑色素瘤的消退率与3号染色体单体状态之间的关系。
我们对接受睫状体/脉络膜黑色素瘤活检及近距离放射治疗的患者进行了一项前瞻性连续病例系列研究。在放置放射性斑块时进行的肿瘤活检采用荧光原位杂交分析，以确定具有3号染色体单体的肿瘤细胞百分比。消退率计算为3个月、6个月和12个月时肿瘤高度的变化百分比。通过单变量线性回归（R版本3.1.0）评估消退率与肿瘤位置、初始肿瘤高度和3号染色体单体（百分比）之间的关系。
纳入研究的75例患者中，8例为睫状体黑色素瘤，67例为脉络膜黑色素瘤。诊断时的平均肿瘤高度为5.2毫米（范围：1.90 - 13.00）。3号染色体单体的百分比组成范围为0 - 20%（n = 35）至81 - 100%（n = 40）。3个月、6个月和12个月时肿瘤高度的消退与肿瘤位置（睫状体或脉络膜）、初始肿瘤高度或3号染色体单体（百分比）无统计学相关性。
近距离放射治疗后脉络膜黑色素瘤的消退率与3号染色体单体状态无关。
