Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Department of Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health, The University of Arizona, Tucson, AZ, USA.
Am J Mens Health. 2023 Jan-Feb;17(1):15579883231153018. doi: 10.1177/15579883231153018.
Birthplace, as a proxy for environmental exposures (e.g., diet), may influence metabolomic profiles and influence risk of cancer. This secondary analysis investigated metabolomic profile differences between foreign and U.S.-born Mexican-origin (MO) Hispanic men to shed light on potential mechanisms through which foreign- and U.S.-born individuals experience differences in cancer risk and risk factors. Plasma samples from MO Hispanic men ( = 42) who participated in a previous lifestyle intervention were collected pre-and post-intervention. Metabolomic profiles were characterized from samples using ultra performance liquid chromatography-quadrupole time of flight mass spectrometry (UPLC-QTOF). Models were visualized using supervised orthogonal projections to latent structures-discriminant analysis (OPLS-DA). Progenesis QI was used for peak integration and metabolite identification. Plasma metabolomic profiles differed between foreign- and U.S.-born pre-intervention (R2 = .65) and post-intervention (R2 = .62). Metabolomic profiles differed pre- versus post-intervention (R2 = .35 and R2 = .65) for the foreign- and U.S.-born group, respectively. Both endogenous metabolites and dietary components characterized differences between foreign- and U.S.-born participants pre- and post-intervention. Plasma metabolomic profiles from MO Hispanic men differed by birthplace. These results advance our understanding of relevant exposures that may affect cancer risk among MO Hispanic men born abroad or in the United States.
出生地可作为环境暴露（例如饮食）的替代指标，可能会影响代谢组学特征，并影响癌症风险。本二次分析旨在研究外国出生和美国出生的墨西哥裔（MO）西班牙裔男性之间代谢组学特征的差异，以阐明潜在机制，说明外国出生和美国出生的个体在癌症风险和风险因素方面存在差异的原因。本研究采集了先前参加生活方式干预研究的 MO 西班牙裔男性（n = 42）的干预前后血浆样本。使用超高效液相色谱-四极杆飞行时间质谱法（UPLC-QTOF）对样本的代谢组学特征进行了描述。使用正交偏最小二乘判别分析（OPLS-DA）对模型进行可视化。使用 Progenesis QI 进行峰积分和代谢物鉴定。外国出生和美国出生的男性在干预前（R2 =.65）和干预后（R2 =.62）的血浆代谢组学特征存在差异。在干预前和干预后，外国出生和美国出生组的代谢组学特征分别存在差异（R2 =.35 和 R2 =.65）。内源性代谢物和饮食成分均可区分干预前后外国出生和美国出生参与者的特征。MO 西班牙裔男性的血浆代谢组学特征因出生地而异。这些结果增进了我们对可能影响出生在国外或美国的 MO 西班牙裔男性癌症风险的相关暴露因素的理解。
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