营养性佝偻病的治疗方法。

Approach to nutritional rickets.

作者信息

Korkmaz Hüseyin Anıl, Padidela Raja, Ozkan Behzat

机构信息

Department of Pediatrics, Division of Pediatric Endocrinology, Dr. Behçet Uz Pediatric Diseases and Surgery training and Research hospital, İzmir, Türkiye.

Department of Paediatric Endocrinology, Royal Manchester Children's Hospital and Faculty of Biology, Medicine & Health, University of Manchester, Manchester, UK.

出版信息

J Pediatr Endocrinol Metab. 2023 Feb 28;36(4):335-341. doi: 10.1515/jpem-2023-0051. Print 2023 Apr 25.

DOI:10.1515/jpem-2023-0051

PMID:36843296

Abstract

Rickets is the disease of a growing skeleton and results from impaired apoptosis of hypertrophic chondrocytes and mineralization of the growth plate. Nutritionally induced rickets, secondary to vitamin D and/or calcium deficiency, remains a major global problem. In this review, we discuss pathogenesis, clinical signs, investigation and management of nutritional rickets.

摘要

佝偻病是一种影响骨骼生长的疾病，由肥大软骨细胞凋亡受损和生长板矿化障碍所致。营养缺乏引起的佝偻病，继发于维生素D和（或）钙缺乏，仍是一个全球性主要问题。在这篇综述中，我们讨论营养性佝偻病的发病机制、临床症状、检查及治疗。