Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.
Gut Liver. 2023 Sep 15;17(5):674-683. doi: 10.5009/gnl220417. Epub 2023 Feb 27.
Acute liver failure (ALF) is a severe liver disease syndrome with rapid deterioration and high mortality. Liver transplantation is the most effective treatment, but the lack of donor livers and the high cost of transplantation limit its broad application. In recent years, there has been no breakthrough in the treatment of ALF, and the application of stem cells in the treatment of ALF is a crucial research field. Mesenchymal stem cells (MSCs) are widely used in disease treatment research due to their abundant sources, low immunogenicity, and no ethical restrictions. Although MSCs are effective for treating ALF, the application of MSCs to ALF needs to be further studied and optimized. In this review, we discuss the potential mechanisms of MSCs therapy for ALF, summarize some methods to enhance the efficacy of MSCs, and explore optimal approaches for MSC transplantation.
急性肝衰竭（ALF）是一种具有快速恶化和高死亡率的严重肝脏疾病综合征。肝移植是最有效的治疗方法，但供体肝脏的缺乏和移植的高成本限制了其广泛应用。近年来，ALF 的治疗没有取得突破，干细胞在 ALF 治疗中的应用是一个关键的研究领域。间充质干细胞（MSCs）由于来源丰富、免疫原性低、无伦理限制，在疾病治疗研究中得到了广泛应用。尽管 MSCs 对 ALF 的治疗有效，但 MSCs 在 ALF 中的应用仍需进一步研究和优化。在这篇综述中，我们讨论了 MSCs 治疗 ALF 的潜在机制，总结了一些增强 MSCs 疗效的方法，并探讨了 MSC 移植的最佳方法。
