Chutko L S, Surushkina S Yu, Yakovenko E A, Anisimova T I, Sergeev A V, Timosheva Y A, Chekalova S A, Madjidova E N, Didur M D, Cherednichenko D V
N. Bekhtereva Institute of Human Brain Russian Academy of Sciences, St. Petersburg, Russia.
Research Institute of Hygiene and Health of Children and Adolescents Federal State Autonomous Institution «NMIC for Children's Health» of the Ministry of Health of the Russian Federation, Moskow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2023;123(2):97-103. doi: 10.17116/jnevro202312302197.
To evaluate the therapeutic efficacy of Pantogam aktiv in the treatment of clinical manifestations of burnout in mothers of children with ADHD.
Under observation were 108 mothers of children with attention deficit hyperactivity disorder (ADHD) aged 25 to 50 years, who had symptoms of burnout in the clinical picture during the initial visit. The following research methods were used in the work: clinical history taking, neurological examination, S. Maslach questionnaire for assessing the burnout manifestations, subjective asthenia rating scale (MFI-20) with five subscales, digital fatigue rating scale (10-point variant), quantitative assessment of autonomic changes (questionnaire A.M. Wein), Spielberger-Khanin Scale for assessing emotional disorders, psychophysiological study of cognitive functions: test of attention variables TOVA (the Test of Variables of Attention). For the treatment of patients, the drug Pantogam Active was used in capsules of 300 mg, at a daily dose of 900 mg (2 capsules in the morning and 1 capsule in the afternoon) for 8 weeks.
A re-examination after a course of treatment showed improvement in 68.5% of patients. After treatment, there was a significant decrease in the severity of such indicators of burnout as emotional exhaustion and depersonalization, a significant decrease in the average values according to the A.M. Wayne, a decrease in reactive anxiety, a statistically significant improvement in attention and a decrease in impulsivity (<0.05).
Thus, the results of the study indicate that the use of Pantogam active in the treatment of clinical manifestations of parental burnout is characterized by high efficiency. After treatment, there is a significant decrease in fatigue, asthenia, anxiety, and total indicators characterizing burnout. The data obtained make it possible to recommend the use of Pantogam aktiv in the treatment of clinical manifestations of parents burnout in children with neurological diseases.
评估泛硫乙胺活性制剂治疗多动症患儿母亲倦怠临床表现的疗效。
观察了108名年龄在25至50岁之间、患有注意力缺陷多动障碍（ADHD）患儿的母亲，她们在初诊时临床表现有倦怠症状。研究工作采用了以下研究方法：临床病史采集、神经学检查、用于评估倦怠表现的马氏倦怠量表、包含五个子量表的主观乏力评定量表（MFI - 20）、数字疲劳评定量表（10分制）、自主神经变化的定量评估（A.M. 韦恩问卷）、用于评估情绪障碍的斯皮尔伯格 - 卡宁量表、认知功能的心理生理学研究：注意力变量测试TOVA（注意力变量测试）。对患者进行治疗时，使用300毫克胶囊装的泛硫乙胺活性制剂，每日剂量为900毫克（早上2粒胶囊，下午1粒胶囊），持续8周。
一个疗程治疗后的复查显示，68.5%的患者病情有所改善。治疗后，倦怠的情绪耗竭和去人格化等指标的严重程度显著降低，根据A.M. 韦恩量表的平均值显著下降，反应性焦虑降低，注意力有统计学意义的改善，冲动性降低（<0.05）。
因此，研究结果表明，使用泛硫乙胺活性制剂治疗父母倦怠的临床表现具有高效性。治疗后，疲劳、乏力、焦虑以及表征倦怠总体指标显著下降。所获数据使得推荐使用泛硫乙胺活性制剂治疗神经疾病患儿父母的倦怠临床表现成为可能。
