Takebuchi Yuki, Minatogawa Airi, Naito Yumi, Sano Chiaki, Ohta Ryuichi
Family Medicine, Shimane University Medical School, Izumo, JPN.
Family Medicine, International University of Health and Welfare, Tokyo, JPN.
Cureus. 2023 Jan 23;15(1):e34090. doi: 10.7759/cureus.34090. eCollection 2023 Jan.
Hypereosinophilic syndrome is a disease that presents with a variety of symptoms caused by an abnormal rise in eosinophils in the blood and infiltration into various organs. Typical symptoms include skin symptoms and diarrhea. Diagnosis may be difficult because of the self-limiting phases of the disease with various symptoms. In addition, diagnosis may be delayed by the presence of rare concomitant symptoms, such as muscle pain and numbness. Here, we report the case of a 67-year-old patient with asymptomatic hypereosinophilia with chronic diarrhea, acute-onset weakness, and myalgia. We diagnosed eosinophilic gastroenteropathy, chronic urticaria, and eosinophilic myositis through multiple biopsies of the skin and colon. This case shows that chronic hypereosinophilic syndrome can be exacerbated transiently with acute symptoms and that prompt examination and treatment of hypereosinophilic syndrome based on the involved organs is recommended in a background of eosinophilia.
高嗜酸性粒细胞综合征是一种因血液中嗜酸性粒细胞异常增多并浸润到各个器官而出现多种症状的疾病。典型症状包括皮肤症状和腹泻。由于该疾病存在具有各种症状的自限阶段，诊断可能会很困难。此外，罕见的伴随症状如肌肉疼痛和麻木的存在可能会导致诊断延迟。在此，我们报告一例67岁患者，患有无症状性高嗜酸性粒细胞增多症，伴有慢性腹泻、急性起病的虚弱和肌痛。我们通过对皮肤和结肠进行多次活检，诊断为嗜酸性粒细胞性胃肠病、慢性荨麻疹和嗜酸性粒细胞性肌炎。该病例表明，慢性高嗜酸性粒细胞综合征可因急性症状而短暂加重，在嗜酸性粒细胞增多的背景下，建议根据受累器官对高嗜酸性粒细胞综合征进行及时检查和治疗。
