Mathuram Thiyagarajan Umasankar, Dajani Khaled, Anderson Blaire, Bigam David, James Shapiro A M
Department of Hepatobiliary and Pancreatic Surgery and Transplantation, University of Alberta Hospital, Edmonton, CAN.
Department of Surgery, Medicine, and Surgical Oncology, University of Alberta Hospital, Edmonton, CAN.
Cureus. 2023 Jan 23;15(1):e34087. doi: 10.7759/cureus.34087. eCollection 2023 Jan.
The coronavirus disease 2019 (COVID-19) pandemic created an unprecedented challenge for healthcare, and the world continues to struggle in recovering from its aftermath. COVID-19 has been clearly linked to hypercoagulable states and can lead to end-organ ischemia, morbidity, and mortality. Immunosuppressed solid organ transplant recipients represent a highly vulnerable population for the increased risk of complications and mortality. Early venous or arterial thrombosis with acute graft loss after whole pancreas transplantation is well-described, but late thrombosis is rare. We herein report a case of acute, late pancreas graft thrombosis at 13 years post pancreas-after-kidney (PAK) transplantation coinciding with an acute COVID-19 infection in a previously double-vaccinated recipient.
2019年冠状病毒病（COVID-19）大流行给医疗保健带来了前所未有的挑战，世界仍在努力从其后果中恢复。COVID-19已被明确与高凝状态相关联，并可导致终末器官缺血、发病和死亡。免疫抑制的实体器官移植受者是并发症和死亡风险增加的高度脆弱人群。全胰腺移植后早期静脉或动脉血栓形成伴急性移植物丢失已有详细描述，但晚期血栓形成罕见。我们在此报告一例肾后胰腺（PAK）移植13年后发生的急性晚期胰腺移植物血栓形成病例，该病例发生在一名先前已接种两剂疫苗的受者身上，同时伴有急性COVID-19感染。
