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使用Regentime技术用自体骨髓来源干细胞治疗颞下颌关节退行性疾病:一例报告

Degenerative Disorder of the Temporomandibular Joint Treated With Autologous Bone Marrow-Derived Stem Cells Using the Regentime Technique: A Case Report.

作者信息

Boulos Rita T, Najjoum Cynthia F, El Asmar Elsa A, Abi Chahine Nassim H

机构信息

Stem Cell Transplantation/Neurology, ACE Cells Lab UK Ltd., Sheffield Rotherham, GBR.

Stem Cell Transplantation/Infectious Diseases/Immunology, ACE Cells Lab UK Ltd., Sheffield Rotherham, GBR.

出版信息

Cureus. 2023 Jan 23;15(1):e34092. doi: 10.7759/cureus.34092. eCollection 2023 Jan.

Abstract

Temporomandibular joint (TMJ) disease is a type of degenerative musculoskeletal disorder that leads to morphological and functional abnormalities. It has a poorly understood progression with numerous independent and interrelated factors, which makes it difficult for the available treatment options to meet long-term demands.  We present the case of a 37-year-old woman who suffered from excruciating pain in the right temporomandibular joint, associated with limited mandibular movement. She was found to have imaging features of TMJ disorder. She underwent the Regentime procedure which uses autologous bone marrow-derived stem cells that are partially differentiated and redirected to the targeted tissue. Clinical follow-up showed total clinical recovery.

摘要

颞下颌关节(TMJ)疾病是一种退行性肌肉骨骼疾病,会导致形态和功能异常。其进展情况尚不清楚,涉及众多独立且相互关联的因素,这使得现有的治疗方案难以满足长期需求。我们报告了一例37岁女性病例,该患者右颞下颌关节剧痛,伴有下颌运动受限。经检查发现她具有颞下颌关节紊乱的影像学特征。她接受了Regentime手术,该手术使用自体骨髓来源的干细胞,这些干细胞经过部分分化后被重定向至目标组织。临床随访显示患者完全康复。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77b0/9946899/f419772d147d/cureus-0015-00000034092-i01.jpg

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