Chen Yu-Hsin, Chen Chenyi, Jian Hong-Yu, Chen Yu-Chun, Fan Yang-Teng, Yang Chih-Yung, Cheng Yawei
Department of Physical Medicine & Rehabilitation, National Yang Ming Chiao Tung University Hospital, Yilan 260, Taiwan.
Institute of Neuroscience and Brain Research Center, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.
Brain Commun. 2023 Feb 4;5(1):fcad022. doi: 10.1093/braincomms/fcad022. eCollection 2023.
Patients with Type 2 diabetes are known to be more susceptible to experience dementia and depression/anxiety. The neural circuits of emotional conflict monitoring, as indicated by a Stroop task, might become altered in terms of cognitive and affective impairments in diabetes. This study investigated alterations in the emotional conflict monitoring and associations of corresponding brain activities with metabolic parameters in persons with Type 2 diabetes. Participants with normal cognitive and affective functioning, including 40 persons with Type 2 diabetes and 30 non-diabetes control subjects, underwent a functional MRI paradigm with the face-word emotional Stroop task and detailed cognitive and affective assessments, including the Montreal Cognitive Assessment and Beck Anxiety Inventory. Compared with the controls, people with diabetes exhibited stronger emotional interference, as indicated by differential reaction times between congruent and incongruent trials (Δcon). Δcon was correlated with Montreal Cognitive Assessment test scores and fasting glucose levels. People with diabetes demonstrated altered brain activation and functional connectivity in the neural network for emotional conflict monitoring. The neural network for emotional conflict monitoring mediated the association of pancreatic function with anxiety scores as well as the relationship between Δcon and Montreal Cognitive Assessment scores. Results suggested that alterations in the neural network underlying emotional conflict monitoring might present before clinically measurable cognitive and affective decrements were apparent, thereby bridging the gap between dementia and anxiety/depression in persons with diabetes.
众所周知，2型糖尿病患者更容易患痴呆症和抑郁/焦虑症。如Stroop任务所示，情绪冲突监测的神经回路可能会因糖尿病患者的认知和情感障碍而发生改变。本研究调查了2型糖尿病患者情绪冲突监测的变化以及相应大脑活动与代谢参数之间的关联。认知和情感功能正常的参与者，包括40名2型糖尿病患者和30名非糖尿病对照受试者，接受了功能性磁共振成像范式，其中包括面部-单词情绪Stroop任务以及详细的认知和情感评估，包括蒙特利尔认知评估和贝克焦虑量表。与对照组相比，糖尿病患者表现出更强的情绪干扰，这可通过一致试验和不一致试验之间的反应时间差异（Δcon）来表明。Δcon与蒙特利尔认知评估测试分数和空腹血糖水平相关。糖尿病患者在情绪冲突监测神经网络中表现出大脑激活和功能连接的改变。情绪冲突监测神经网络介导了胰腺功能与焦虑评分之间的关联以及Δcon与蒙特利尔认知评估分数之间的关系。结果表明，情绪冲突监测潜在神经网络的改变可能在临床上可测量的认知和情感衰退明显之前就已出现，从而弥合了糖尿病患者痴呆症与焦虑/抑郁症之间的差距。
